肝脏和胰腺:相似的胚胎发育和组织结构导致相似的肿瘤发生机制吗?

Q2 Biochemistry, Genetics and Molecular Biology Gene expression Pub Date : 2018-08-22 Epub Date: 2018-03-26 DOI:10.3727/105221618X15216414278706

Elsa Ghurburrun, Ivan Borbath, Frédéric P Lemaigre, Patrick Jacquemin

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引用次数: 14

摘要

肝脏和胰腺是密切相关的器官，具有共同的胚胎起源。它们表现出两栖性质，与实质细胞(即肝细胞和腺泡细胞)具有相似的外分泌组织，通过胆管和胰管的会聚网络向十二指肠分泌胆汁和胰液。在这里，我们比较并强调导致肝癌和胰腺癌发展的分子机制的相似性。我们认为，揭示肿瘤在一个器官中的发展可能为我们理解其他器官的癌变提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Liver and Pancreas: Do Similar Embryonic Development and Tissue Organization Lead to Similar Mechanisms of Tumorigenesis?

The liver and pancreas are closely associated organs that share a common embryological origin. They display amphicrine properties and have similar exocrine organization with parenchymal cells, namely, hepatocytes and acinar cells, secreting bile and pancreatic juice into the duodenum via a converging network of bile ducts and pancreatic ducts. Here we compare and highlight the similarities of molecular mechanisms leading to liver and pancreatic cancer development. We suggest that unraveling tumor development in an organ may provide insight into our understanding of carcinogenesis in the other organ.

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.