Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes
{"title":"n -乙酰半胱氨酸对stz诱导糖尿病大鼠血脂异常及碳水化合物代谢的影响。","authors":"Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes","doi":"10.1155/2018/6428630","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.</p><p><strong>Method: </strong>32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (<i>n</i> = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water <i>ad libitum</i>. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.</p><p><strong>Results: </strong>NAC decreased (<i>p</i> < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (<i>p</i> < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (<i>p</i> < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.</p><p><strong>Conclusion: </strong>NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.</p>","PeriodicalId":14448,"journal":{"name":"International Journal of Vascular Medicine","volume":"2018 ","pages":"6428630"},"PeriodicalIF":2.5000,"publicationDate":"2018-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6428630","citationCount":"14","resultStr":"{\"title\":\"Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.\",\"authors\":\"Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes\",\"doi\":\"10.1155/2018/6428630\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.</p><p><strong>Method: </strong>32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (<i>n</i> = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water <i>ad libitum</i>. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.</p><p><strong>Results: </strong>NAC decreased (<i>p</i> < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (<i>p</i> < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (<i>p</i> < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.</p><p><strong>Conclusion: </strong>NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.</p>\",\"PeriodicalId\":14448,\"journal\":{\"name\":\"International Journal of Vascular Medicine\",\"volume\":\"2018 \",\"pages\":\"6428630\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2018-01-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2018/6428630\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Vascular Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2018/6428630\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Vascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2018/6428630","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.
Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.
Method: 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.
Results: NAC decreased (p < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.
Conclusion: NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
