儿童/青少年甲状腺乳头状癌术后甲状腺球蛋白倍增时间提示肿瘤生长的自发减缓和消退。

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2018-05-16 eCollection Date: 2018-01-01 DOI:10.1155/2018/6470251
Toshihiko Kasahara, Akira Miyauchi, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Yasuhiro Ito, Minoru Kihara, Akihiro Miya
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引用次数: 6

摘要

背景:儿童和青少年甲状腺乳头状癌(ptc)通常预后良好,尽管他们经常扩展疾病。年轻ptc患者术后肿瘤生长可能自发减慢。我们比较了年轻PTC患者术后甲状腺球蛋白加倍时间(Tg-DT)与术前假设肿瘤体积加倍时间(hTV-DT)。方法:1998-2016年在熊马医院行甲状腺全切除术的14例年龄≤18岁的PTC患者术后存在生化持续性疾病。我们计算了他们的tg - dt,并根据肿瘤大小和患者手术时的年龄估计了他们术前的tv - dt,假设患者出生时只有一个癌细胞。结果:12例患者tg - dt呈阳性,时间从2.0年到147年不等,其余2例患者tg - dt呈阴性,表现为生长缓慢甚至倒退。htv - dt为0.3 ~ 0.6年(中位0.5年),明显短于tg - dt (p < 0.001),表明术前生长快得多。未给予放射性碘(RAI)的9例患者的分析结果相似(p < 0.01)。结论:与RAI无关,患者术后tg - dt明显长于术前htv - dt, 2例患者ptc为负值,说明这些年轻患者术后ptc的生长自发减慢甚至倒退。
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Spontaneous Slowing and Regressing of Tumor Growth in Childhood/Adolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time.

Background: Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients' PTCs might show spontaneous slowing postoperatively. We compared young PTC patients' postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT).

Methods: Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998-2016 had biochemically persistent disease postoperatively. We calculated their Tg-DTs and estimated their preoperative TV-DTs with the tumor size and the patient's age at surgery, presuming that a single cancer cell was present at the patient's birth.

Results: Twelve patients had positive Tg-DTs ranging from 2.0 to 147 years, and the remaining two had negative Tg-DTs, indicating slow growth or even regression. The hTV-DTs were 0.3-0.6 years (median 0.5 years), which were significantly shorter than the Tg-DTs (p < 0.001), indicating much faster growth preoperatively. The analyses of the nine patients without radioactive iodine administration (RAI) gave similar results (p < 0.01).

Conclusions: Irrespective of RAI, the patients' postoperative Tg-DTs were significantly longer than their preoperative hTV-DTs and were negative values in two patients, indicating that the growth of these young patients' PTCs had spontaneously slowed or even regressed postoperatively.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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