[微流控芯片技术研究荆芥诱导癌细胞凋亡]。

药学学报 Pub Date : 2017-01-01

Jia-xin Fan, Shuai Wang, Xian-sheng Meng, Yong-rui Bao, Tian-jiao Li

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引用次数: 0

摘要

本研究旨在阐明荆芥乙醇提取物的化学成分及其抗癌作用。采用微流控技术对9个不同地理区域的荆芥进行了研究。采用高效液相色谱法测定乙醇提取物的指纹图谱，通过灰色关联软件分析其光谱与功效指标之间的关系，并建立快速HPLC- q - tof /MS方法。结果表明，第19、6、11、16、18个色谱峰为代表性的薯蓣皂苷、木犀草苷、橙皮苷、木犀草素和芹菜素。第10、12、20个峰可能是柚皮素-7- o -葡萄糖苷或槲皮苷，迭香酸盐或乙酰花椰菜碱，5,7-二羟基-6,4-二甲氧基黄酮。荆芥的主要化学成分具有抗肺肿瘤作用。建立了中药质量控制的新方法。

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[Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology].

This study was designed to elucidate the chemical composition and anti-cancer effects of Schizonepeta tenuifolia’s ethanol extracts. Microfluidic technology was used in the study of Schizonepeta tenuifolia from 9 different geographic regions. The ethanol extracts were examined with HPLC to establish their Fingerprints in order to analyze the relationship between the spectrum and efficacy index through Grey Correlation software, and a rapid HPLC-Q-TOF/MS method was established. The result shows that chromatographic peaks of the 19, 6, 11, 16, 18th are the representative diosmetin, luteoloside, hesperidin, luteolin, and apigenin. The 10, 12, 20th peaks may be naringenin-7-O-glucuronide or quercitrin, rosmarinate or acetylcorynoline, and 5,7-dihydroxy-6,4-dimethoxy flavone. The major chemical composition of Schizonepeta tenuifolia was found to have the anti-lung-tumor effects. A new method was established for the quality control of traditional Chinese medicine.

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.