【元湖止痛方化学成分的HPLC-QTOF/MS鉴别】。

药学学报 Pub Date : 2017-01-01

Yan-qi Han, Jun Xu, Su-xiao Gong, Tie-jun Zhang, Chang-xiao Liu

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引用次数: 0

摘要

为了明确元湖止痛方(YHZT)的化学成分，建立了高效液相色谱/电喷雾电离四倍飞行时间质谱(HPLC-QTOF/MS)快速分析方法。基于高分辨率质谱数据、片段离子信息、参考标准品数据和文献报道，共鉴定出51个峰，其中生物碱类化合物28个，香豆素类化合物23个。对YHZT中的化学成分进行了快速、准确、系统的分析。研究结果为YHZT有效成分的质量控制奠定了基础。

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[Identification of chemical constituents of Yuanhu Zhitong prescription by HPLC-QTOF/MS].

This study was designed to clarify the chemical constituents in Yuanhu Zhitong prescription (YHZT), a rapid high performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (HPLC-QTOF/MS) method was established. Based on the high resolution MS spectra data, fragment ion information, reference standards data and literature reports, 51 peaks including 28 alkaloid compounds and 23 coumarin compounds were identified. The chemical constituents in YHZT were rapidly, accurately, systematically analyzed. The results lay a foundation for the quality control of effective compounds of YHZT.

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.