【硫化氢与糖尿病及糖尿病并发症的研究进展】。

生理科学进展 Pub Date : 2018-06-21

Yue Gu, Li-Ping Xie, Guo-Liang Meng, Yong Ji

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引用次数: 0

摘要

糖尿病及其并发症继续成为一个日益严重的全球健康问题。硫化氢(H2S)是继一氧化氮和一氧化碳之后在体内出现的第三种气体递质，在生理和病理生理中都起着重要的作用。最近的研究表明H2S在调节胰腺β细胞功能，胰岛素抵抗和糖尿病并发症的发展中起重要作用。靶向H2S是治疗糖尿病及其相关并发症的一种新方法。这篇综述文章总结了目前关于H2S在糖尿病中的作用的证据，特别是在其相关血管并发症中，以及潜在的信号机制。

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[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications].

Diabetes and its complications continue to be an increasing global health problem. Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology. Recent work has suggested important roles for H2S in the regulation of pancreatic β-cell function, as well as development of insulin resistance and diabetic complications. Targeting H2S represents a novel therapeutic approach in diabetes and its associated complications. This review article summarizes the current body of evidence regarding the role of H2S in diabetes mellitus, and especially in its associated vascular complications, as well as the underlying signaling mechanisms.

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生理科学进展

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5953

期刊介绍： Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.

期刊最新文献

[Neuropeptide Y]. [Pancreastatin]. [Proteoglycan]. [Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications]. [Cardiovascular Regulation by Sulfur-containing Gaseous Signaling Molecules and the Underlying Mechanisms:Updated Research Evidence].