G蛋白偶联受体的膜运输和信号系统的进化观点。

Silvia Sposini, Aylin C Hanyaloglu
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引用次数: 11

摘要

G蛋白偶联受体(GPCR)超家族激活复杂的信号通路,然而解开这些信号系统以了解受体信号通路的特异性是如何实现的,一直是一个具有挑战性的问题。膜转运在GPCR信号调节中的作用最近经历了范式转变,从编程质膜G蛋白信号谱的机制到提供对体内指定受体功能至关重要的独特信号平台。在本章中,我们讨论了我们对gpcr所使用的内吞运输系统的理解的演变,以及这些系统如何与信号传导深度集成。我们描述了最近的研究表明,膜室可以提供一种机制,既指定,但也多样化,GPCR信号转导。这些新的进化模型有助于对复杂疾病的机制理解,并提供新的治疗途径。
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Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors.

The G protein-coupled receptor (GPCR) superfamily activates complex signal pathways, yet untangling these signaling systems to understand how specificity in receptor signaling pathways is achieved, has been a challenging question. The roles of membrane trafficking in GPCR signal regulation has undergone a recent paradigm shift, from a mechanism that programs the plasma membrane G protein signaling profile to providing distinct signaling platforms critical for specifying receptor function in vivo. In this chapter, we discuss this evolution of our understanding in the endocytic trafficking systems employed by GPCRs, and how such systems play a deeply integrated role with signaling. We describe recent studies that suggest that the endomembrane compartment can provide a mechanism to both specify, and yet also diversify, GPCR signal transduction. These new evolving models could aid mechanistic understanding of complex disease and provide novel therapeutic avenues.

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CiteScore
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期刊介绍: Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.
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