脑外伤后细胞屏障的作用及诊断意义。

Q3 Medicine Concussion Pub Date : 2018-01-31 eCollection Date: 2018-03-01 DOI:10.2217/cnc-2017-0019
Aaron Dadas, Damir Janigro
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引用次数: 24

摘要

头部震荡创伤的发生通常会引发一系列复杂的生理后果和病理生理反应。这些后遗症可以是急性的(如血肿)或慢性的(如自身免疫反应、神经退行性变等),并且可以随任何严重程度的创伤而发生。预测脑震荡后预后的一个关键因素是细胞屏障的病理生理反应,这可以通过急性和慢性损伤后阶段的几种生物标志物来测量。我们在此综述了脑震荡后血脑屏障的机制,以及利用这一边界的差异生物标志物表达的诊断/预后方法。我们讨论了血液-唾液细胞屏障作为血液中脑源性生物标志物的调节过滤器的作用,以及它对基于唾液的诊断分析的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The role and diagnostic significance of cellular barriers after concussive head trauma.

The onset of concussive head trauma often triggers an intricate sequence of physical consequences and pathophysiological responses. These sequelae can be acute (i.e., hematoma) or chronic (i.e., autoimmune response, neurodegeneration, etc.), and may follow traumas of any severity. A critical factor for prognostication of postconcussion outcome is the pathophysiological response of cellular barriers, which can be measured by several biomarkers of the acute and chronic postinjury phases. We present herein a review on the postconcussion mechanisms of the blood-brain barrier, as well as the diagnostic/prognostic approaches that utilize differential biomarker expression across this boundary. We discuss the role of the blood-saliva cellular barrier as a regulatory filter for brain-derived biomarkers in blood, and its implications for saliva-based diagnostic assays.

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来源期刊
Concussion
Concussion Medicine-Neurology (clinical)
CiteScore
2.70
自引率
0.00%
发文量
2
审稿时长
12 weeks
期刊最新文献
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