2型糖尿病和糖尿病肾病患者的甲状腺功能:一项单中心研究

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2018-12-02 eCollection Date: 2018-01-01 DOI:10.1155/2018/9507028
Wei Zhao, Xinyu Li, Xuhan Liu, Lu Lu, Zhengnan Gao
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引用次数: 24

摘要

背景:糖尿病是一种常见的代谢性疾病,发病率呈快速上升趋势。甲状腺疾病包括亚临床甲状腺功能减退症(SCH)和低三碘甲状腺原氨酸(T3)综合征在糖尿病患者中经常观察到。我们进行了一项研究,探讨2型糖尿病(T2DM)和糖尿病肾病(DN)患者的甲状腺功能。方法:我们纳入103名健康志愿者,100名无DN的T2DM患者和139名DN患者。体格检查包括体重指数和血压,实验室测量包括肾功能、甲状腺功能和糖化血红蛋白。结果:DN患者促甲状腺激素(TSH)水平高于非DN患者,游离T3 (FT3)水平低于非DN患者(p < 0.01)。DN患者SCH和低FT3综合征患病率分别为10.8%和20.9%,高于对照组和非DN患者(p < 0.05)。通过Pearson相关或Spearman秩相关分析,DN患者TSH与血清肌酐(r = 0.363, p = 0.013)、尿白蛋白/肌酐比(r = 0.337, p = 0.004)呈正相关,FT3与肾小球滤过率(eGFR)估测呈正相关,差异均有统计学意义(r = 0.560, p < 0.001)。结论:T2DM合并DN患者TSH水平高,FT3水平低。常规监测DN患者的甲状腺功能是必要的,甲状腺功能障碍的管理可能是DN的潜在治疗策略。
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Thyroid Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy: A Single Center Study.

Background: Diabetes mellitus is a common metabolic disease and the prevalence is increasing rapidly. Thyroid disorders including subclinical hypothyroidism (SCH) and low triiodothyronine (T3) syndrome are frequently observed in diabetic patients. We conducted a study to explore thyroid function in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN).

Methods: We included 103 healthy volunteers, 100 T2DM patients without DN, and 139 with DN. Physical examinations including body mass index and blood pressure and laboratory measurements including renal function, thyroid function, and glycosylated hemoglobin were conducted.

Results: Patients with DN had higher thyroid stimulating hormone (TSH) levels and lower free T3 (FT3) levels than those without DN (p < 0.01). The prevalence of SCH and low FT3 syndrome in patients with DN was 10.8% and 20.9%, respectively, higher than that of controls and patients without DN (p < 0.05). Through Pearson correlation or Spearman rank correlation analysis, in patients with DN, there were positive correlations in TSH with serum creatinine (r = 0.363, p = 0.013) and urinary albumin-to-creatinine ratio (r = 0.337, p = 0.004), and in FT3 with estimated glomerular filtration rate (eGFR) with statistical significance (r = 0.560, p < 0.001).

Conclusions: High level of TSH and low level of FT3 were observed in T2DM patients with DN. Routine monitoring of thyroid function in patients with DN is necessary, and management of thyroid dysfunction may be a potential therapeutic strategy of DN.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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