[Presepsin与降钙素原在脓毒症患儿中的临床应用比较]。

Kaori Nakanishi, Satomi Kasashima, Yuko Ishii, Hirokazu Shimoeda, Atsuhiro Kawashima
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引用次数: 0

摘要

诊断败血症非常困难,如果不及时治疗,败血症往往会导致死亡。目前还没有诊断败血症的明确生物标志物,尽管使用各种生物标志物,包括降钙素原(PCT),作为诊断指标被认为是有价值的。自2014年日本批准健康保险覆盖以来,生物标志物presepsin (P- SEP)作为败血症的诊断工具受到了关注。在这项研究中,我们根据是否存在系统性炎症反应综合征和感染将156名儿童分为五组,并比较了这些组的P-SEP和PCT水平。并根据诊断的疾病分为5组,比较各组间P-SEP和PCT水平。脓毒症患者P-SEP水平均超过临界值,其他组患者P-SEP水平几乎不超过临界值。相比之下,脓毒症患者的PCT水平升高,但其他组,特别是局部感染患者的PCT水平也超过了临界值。同样,在诊断疾病的分类过程中,卡wasaki病的PCT水平也升高。综上所述,P-SEP可作为诊断儿童脓毒症的一种有用的生物标志物,值得进一步研究。简短的沟通。
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[Clinical Use of Presepsin Compared with That of Procalcitonin in Children with Sepsis].

Diagnosing sepsis can be very difficult and without prompt treatment, sepsis frequently results in death. No definitive biomarker for diagnosing sepsis currently exists, although the use of various biomarkers, includ- ing procalcitonin (PCT), as diagnostic indicators has been considered valuable. The biomarker presepsin (P- SEP) has gained attention as a diagnostic tool for sepsis since health insurance coverage approval in Japan in 2014. In this study, we categorized 156 children into five groups based on the presence or absence of sys- temic inflammatory response syndrome and infection, and compared the levels of P-SEP and PCT among these groups. Furthermore, they were categorized into five groups based on the diagnosed disease, and the P-SEP and PCT levels were compared among these groups. The P-SEP levels exceeded the cut-off value in all patients with sepsis, and patients of other groups hardly exceeded the cut-off value. In contrast, the PCT levels increased in patients with sepsis, but those in other groups, particularly in local infection, also exceed- ed the cut-off value. Similarly, during the diagnosed disease classification, PCT levels also increased in Ka- wasaki disease. In conclusion, P-SEP could be a useful biomarker for the diagnosis of sepsis in children and should be studied further. [Short Communication].

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