Asma M Elsharif, Tamer E Youssef, Suhailah S Al-Jameel, Hanan H Mohamed, Mohammad Azam Ansari, Suriya Rehman, Sultan Akhtar
{"title":"可活化四取代酞菁镍-4（3H）-喹唑啉酮偶联物的合成及其抗菌活性。","authors":"Asma M Elsharif, Tamer E Youssef, Suhailah S Al-Jameel, Hanan H Mohamed, Mohammad Azam Ansari, Suriya Rehman, Sultan Akhtar","doi":"10.1155/2019/5964687","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)<sub>4</sub>NiPcs <b>4a-d</b>. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)<sub>4</sub>NiPcs <b>4a-d</b> against <i>Escherichia coli</i>. The minimum MICs and MBCs value were recorded for compounds <b>4a</b>, <b>4b</b>, <b>4c</b>, and <b>4d</b>, respectively. The results indicated that the studied (qz)<sub>4</sub>NiPcs <b>4a-d</b> units possessed a broad spectrum of activity against <i>Escherichia coli</i>. Their antibacterial activities were found in the order of <b>4d</b> > <b>4c</b> > <b>4b</b> > <b>4a</b> against <i>Escherichia coli</i>, and the strongest antibacterial activity was achieved with compound <b>4d</b>.</p>","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/5964687","citationCount":"8","resultStr":"{\"title\":\"Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity.\",\"authors\":\"Asma M Elsharif, Tamer E Youssef, Suhailah S Al-Jameel, Hanan H Mohamed, Mohammad Azam Ansari, Suriya Rehman, Sultan Akhtar\",\"doi\":\"10.1155/2019/5964687\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)<sub>4</sub>NiPcs <b>4a-d</b>. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)<sub>4</sub>NiPcs <b>4a-d</b> against <i>Escherichia coli</i>. The minimum MICs and MBCs value were recorded for compounds <b>4a</b>, <b>4b</b>, <b>4c</b>, and <b>4d</b>, respectively. The results indicated that the studied (qz)<sub>4</sub>NiPcs <b>4a-d</b> units possessed a broad spectrum of activity against <i>Escherichia coli</i>. Their antibacterial activities were found in the order of <b>4d</b> > <b>4c</b> > <b>4b</b> > <b>4a</b> against <i>Escherichia coli</i>, and the strongest antibacterial activity was achieved with compound <b>4d</b>.</p>\",\"PeriodicalId\":7389,\"journal\":{\"name\":\"Advances in Pharmacological Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2019/5964687\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Pharmacological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2019/5964687\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Pharmacological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2019/5964687","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity.
The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a-d. The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4NiPcs 4a-d against Escherichia coli. The minimum MICs and MBCs value were recorded for compounds 4a, 4b, 4c, and 4d, respectively. The results indicated that the studied (qz)4NiPcs 4a-d units possessed a broad spectrum of activity against Escherichia coli. Their antibacterial activities were found in the order of 4d > 4c > 4b > 4a against Escherichia coli, and the strongest antibacterial activity was achieved with compound 4d.
期刊介绍：
Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. Topics covered by the journal include, but are not limited to: -Biochemical pharmacology, drug mechanism of action, pharmacodynamics, pharmacogenetics, pharmacokinetics, and toxicology. -The design and preparation of new drugs, and their safety and efficacy in humans, including descriptions of drug dosage forms. -All areas of medicinal chemistry, such as drug discovery, design and synthesis. -Basic biology of drug and gene delivery through to application and development of these principles, through therapeutic delivery and targeting. Areas covered include bioavailability, controlled release, microcapsules, novel drug delivery systems, personalized drug delivery, and techniques for passing biological barriers.
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