在动物实验中口服和鼻内注射纳米颗粒治疗脑缺血:考虑其利弊。

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics Current clinical pharmacology Pub Date : 2020-01-01 DOI:10.2174/1574884714666190704115345
Firoozeh Alavian, Nasrin Shams
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引用次数: 0

摘要

背景:在过去的几十年里,纳米技术从合成现代纳米结构的精确策略到进入人体的方法都有了长足的进步。将纳米技术用于诊断、给药、确定信号通路和组织工程是治疗中风的一大希望。载药纳米粒子是一种通过口腔或鼻腔增加药物吸收以治疗中风的方法:本文除阐述纳米颗粒口服和鼻内给药在动物模型脑缺血治疗中的利弊外,研究人员还介绍了该领域的一些文章,并简要提及了他们的工作成果:方法:研究人员从PubMed、Google Scholar和Scopus等三个常用数据库中初步收集了183篇已发表的相关文章。研究过程中剔除了与本研究主旨无关的文章。本数据集最终包括 125 篇已发表的文章:与全身给药相比,通过口鼻直接向动物大脑给药具有更强的治疗效果。在纳米颗粒复合物中添加药物的策略有可能改善向中枢神经系统直接给药的效果:结论:尽管口服和鼻内给药途径存在局限性,但在脑缺血治疗中,口服和鼻内给药纳米药物的治疗潜力很大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Oral and Intra-nasal Administration of Nanoparticles in the Cerebral Ischemia Treatment in Animal Experiments: Considering its Advantages and Disadvantages.

Background: Over the past few decades, nanotechnology has dramatically advanced; from the precise strategies of synthesizing modern nanostructures to methods of entry into the body. Using nanotechnology in diagnosis, drug delivery, determining signaling pathways, and tissue engineering is great hope for the treatment of stroke. The drug-carrying nanoparticles are a way to increase drug absorption through the mouth or nose in treating the stroke.

Objective: In this article, in addition to explaining pros and cons of oral and intra-nasal administration of nanoparticles in the brain ischemia treatment of animal models, the researchers introduce some articles in this field and briefly mentioned their work outcomes.

Methods: A number of relevant published articles 183 were initially collected from three popular databases including PubMed, Google Scholar, and Scopus. The articles not closely related to the main purpose of the present work were removed from the study process. The present data set finally included 125 published articles.

Results: Direct delivery of the drug to the animal brain through the mouth and nose has more therapeutic effects than systemic delivery of drugs. The strategy of adding drugs to the nanoparticles complex can potentially improve the direct delivery of drugs to the CNS.

Conclusion: Despite the limitations of oral and intra-nasal routes, the therapeutic potential of oral and intra-nasal administration of nano-medicines is high in cerebral ischemia treatment.

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Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
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期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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