益生元对便秘的治疗作用:综述

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics Current clinical pharmacology Pub Date : 2020-01-01 DOI:10.2174/1574884715666200212125035
Maliha Naseer, Shiva Poola, Suleyman Uraz, Veysel Tahan
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引用次数: 12

摘要

便秘是一种非常普遍的功能性胃肠道疾病,可能会显著影响生活质量和医疗保健费用。便秘的治疗已经被广泛地回顾了认知疗法、药物治疗和手术干预。肠道微生物群如双歧杆菌、梭状芽胞杆菌、拟杆菌和乳酸杆菌已被证明在功能性胃肠道疾病和益生元中发挥作用,以增加它们的存在。益生元是食物中未被消化的成分,可以刺激细菌。有多种益生元;然而,只有少数研究描述了它们对慢性便秘的功效。本研究的目的是回顾有关不同市售益生元在功能性和慢性特发性便秘患者中的效用的现有文献。为了实现研究目标,检索了Pubmed、Ovid Medline和EMBASE等数据库中已发表的英文文章。使用益生元,便秘,慢性便秘,功能性便秘等术语。我们回顾并纳入了21项探索益生元在便秘成人中的作用的随机对照试验。益生元是慢性特发性便秘的有效治疗方法,可以改善大便一致性,排便次数和腹胀。尽管哪种益生元配方会促进便秘症状的改善仍不清楚。
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Therapeutic Effects of Prebiotics on Constipation: A Schematic Review.

Constipation is a highly prevalent functional gastrointestinal disorder that may significantly affect the quality of life and health care costs. Treatment for constipation has been broadly reviewed by cognitive therapies, medications, and surgical interventions. Gut microbiota such as Bifidobacterium, Clostridium, Bacteroidetes, and Lactobacilli have been demonstrated in functional gastrointestinal disorders and prebiotics to play a role in augmenting their presence. Prebiotics are ingredients in foods that remain undigested, stimulating the bacteria. There are a variety of prebiotics; however, there exists only a handful of studies that describe their efficacy for chronic constipation. The purpose of this study is to review the available literature on the utility of different commercially available prebiotics in patients with functional and chronic idiopathic constipation. To fulfil the objectives of the study, published articles in the English language on databases such as Pubmed, Ovid Medline, and EMBASE were searched. The terms prebiotics, constipation, chronic constipation, functional constipation were used. We reviewed and included 21 randomized controlled trials exploring the role of prebiotics in constipated adults. Prebiotics are effective treatments for chronic idiopathic constipation and showed improvement in the stool consistency, number of bowel moments and bloating. Although which prebiotic formulary would promote improved symptoms of constipation is still not clear.

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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
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期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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