两亲性葡聚糖-月桂酸乙烯基纳米颗粒:形成、表征、包封和对人肠细胞系的细胞毒性。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2020-06-01 Epub Date: 2020-02-18 DOI:10.1007/s40204-020-00128-1
Pattaramon Kraisomdet, Thiraya Pratess, Pawida Na Nakorn, Pinyapat Sangkaew, Ariya Naneto, Pranee Inprakon, Watanalai Panbangred, Nisa Patikarnmonthon
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引用次数: 2

摘要

右旋糖酐由于其可生物降解和生物相容性,以及以多种方式功能化的能力,已成为治疗应用的模型材料。本研究通过脂肪酶催化右旋糖酐与月桂酸乙烯酯进行酯交换,成功合成了两亲性右旋糖酐。在水溶液中,制备的葡聚糖酯可自组装成直径约200 nm的球形纳米颗粒(“Dex-L NPs”),并可与猪胎盘水解物结合,包封率为60%。此外,Dex-L NPs对人肠道细胞系具有低细胞毒作用,因此口服给药可能是安全的。综上所述,这些发现说明了新开发的纳米颗粒作为一种有效和安全的药物输送系统的潜力。
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Amphiphilic dextran-vinyl laurate-based nanoparticles: formation, characterization, encapsulation, and cytotoxicity on human intestinal cell line.

Dextran has been the model material for the therapeutic applications owing to its biodegradable and biocompatible properties, and the ability to be functionalized in variety of ways. In this study, the amphiphilic dextran was successfully synthesized through lipase-catalyzed transesterification between dextran and vinyl laurate. In aqueous solution, the produced dextran ester could self-assemble into spherical nanoparticles ("Dex-L NPs") with approximately 200-nm diameter, and could incorporate porcine placenta hydrolysate with 60% encapsulation efficiency. Furthermore, Dex-L NPs exhibited low cytotoxic effects on human intestinal cell line and, thus, were potentially safe for oral administration. Taken together, the findings illustrate the potential of the newly developed nanoparticles to serve as an efficient and safe drug delivery system.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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