{"title":"表观遗传学、发育和精神病理学。","authors":"Kieran J O'Donnell, Michael J Meaney","doi":"10.1146/annurev-clinpsy-050718-095530","DOIUrl":null,"url":null,"abstract":"<p><p>Epigenetic mechanisms govern the transcription of the genome. Research with model systems reveals that environmental conditions can directly influence epigenetic mechanisms that are associated with interindividual differences in gene expression in brain and neural function. In this review, we provide a brief overview of epigenetic mechanisms and research with relevant rodent models. We emphasize more recent translational research programs in epigenetics as well as the challenges inherent in the integration of epigenetics into developmental and clinical psychology. Our objectives are to present an update with respect to the translational relevance of epigenetics for the study of psychopathology and to consider the state of current research with respect to its potential importance for clinical research and practice in mental health.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":"16 ","pages":"327-350"},"PeriodicalIF":17.8000,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-clinpsy-050718-095530","citationCount":"35","resultStr":"{\"title\":\"Epigenetics, Development, and Psychopathology.\",\"authors\":\"Kieran J O'Donnell, Michael J Meaney\",\"doi\":\"10.1146/annurev-clinpsy-050718-095530\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Epigenetic mechanisms govern the transcription of the genome. Research with model systems reveals that environmental conditions can directly influence epigenetic mechanisms that are associated with interindividual differences in gene expression in brain and neural function. In this review, we provide a brief overview of epigenetic mechanisms and research with relevant rodent models. We emphasize more recent translational research programs in epigenetics as well as the challenges inherent in the integration of epigenetics into developmental and clinical psychology. Our objectives are to present an update with respect to the translational relevance of epigenetics for the study of psychopathology and to consider the state of current research with respect to its potential importance for clinical research and practice in mental health.</p>\",\"PeriodicalId\":50755,\"journal\":{\"name\":\"Annual Review of Clinical Psychology\",\"volume\":\"16 \",\"pages\":\"327-350\"},\"PeriodicalIF\":17.8000,\"publicationDate\":\"2020-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1146/annurev-clinpsy-050718-095530\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual Review of Clinical Psychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-clinpsy-050718-095530\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/2/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Clinical Psychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1146/annurev-clinpsy-050718-095530","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/2/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHOLOGY","Score":null,"Total":0}
Epigenetic mechanisms govern the transcription of the genome. Research with model systems reveals that environmental conditions can directly influence epigenetic mechanisms that are associated with interindividual differences in gene expression in brain and neural function. In this review, we provide a brief overview of epigenetic mechanisms and research with relevant rodent models. We emphasize more recent translational research programs in epigenetics as well as the challenges inherent in the integration of epigenetics into developmental and clinical psychology. Our objectives are to present an update with respect to the translational relevance of epigenetics for the study of psychopathology and to consider the state of current research with respect to its potential importance for clinical research and practice in mental health.
期刊介绍：
The Annual Review of Clinical Psychology is a publication that has been available since 2005. It offers comprehensive reviews on significant developments in the field of clinical psychology and psychiatry. The journal covers various aspects including research, theory, and the application of psychological principles to address recognized disorders such as schizophrenia, mood, anxiety, childhood, substance use, cognitive, and personality disorders. Additionally, the articles also touch upon broader issues that cut across the field, such as diagnosis, treatment, social policy, and cross-cultural and legal issues.
Recently, the current volume of this journal has transitioned from a gated access model to an open access format through the Annual Reviews' Subscribe to Open program. All articles published in this volume are now available under a Creative Commons Attribution License (CC BY), allowing for widespread distribution and use. The journal is also abstracted and indexed in various databases including Scopus, Science Citation Index Expanded, MEDLINE, EMBASE, CINAHL, PsycINFO, and Academic Search, among others.
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