益生菌对糖尿病肾病的作用:一项系统综述。

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics Current clinical pharmacology Pub Date : 2020-01-01 DOI:10.2174/1574884715666200303112753
Eugenia Vlachou, Anastasia Ntikoudi, Ourania Govina, Maria Lavdaniti, Nikolaos Kotsalas, Athanasios Tsartsalis, George Dimitriadis
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引用次数: 21

摘要

背景:糖尿病肾病是糖尿病的常见并发症,由于多肾间室的功能和结构改变。益生菌最近作为一种即将到来的治疗干预措施而兴起,但到目前为止还没有对糖尿病肾病进行系统的评估。本系统综述的目的是评价随机对照试验和实验研究评估益生菌补充剂对糖尿病肾病的影响。方法:通过PubMed、Scopus、Cinahl和Medline等电子数据库进行广泛的文献检索,检索词为“糖尿病肾病”、“糖尿病肾病”和“益生菌”。检索得到116个结果,其中9个符合本系统评价的纳入标准。结果:研究中使用的微生物大部分属于乳杆菌属和双歧杆菌属。剂量从2×107到6×1010 CFU/ g不等。在不同的研究中,益生菌的形式各不相同(胶囊、小包、豆浆、开菲尔和蜂蜜)。大多数研究表明,在糖尿病肾病患者中,补充益生菌对减少炎症、氧化应激和改善肾功能生物标志物有好处。在益生菌干预期间未观察到重大胃肠道不良事件。结论:本系统综述的结果表明,益生菌对糖尿病肾病的积极影响没有任何主要的不良事件。此外,为了进一步验证益生菌补充对糖尿病肾病的有效性,未来还需要更大规模的随机对照试验,样本量更大,随访时间更长。
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Effects of Probiotics on Diabetic Nephropathy: A Systematic Review.

Background: Diabetic Nephropathy is a frequent complication of diabetes mellitus due to functional and structural modifications in multiple kidney compartments. Probiotics have risen lately as a forthcoming therapeutic intervention but they have not been systematically evaluated in diabetic nephropathy so far. The aim of this systematic review was to evaluate randomized controlled trials and experimental studies assessing the effect of probiotic supplements on diabetic nephropathy.

Methods: An extensive literature search was conducted through electronic databases (PubMed, Scopus, Cinahl and Medline) with the Medical Subject Headings and entry terms of "diabetic nephropathy", "diabetic renal disease" and "probiotics". The search yielded 116 results, 9 of which met the inclusion criteria for this systematic review.

Results: Most of the microorganisms used in the studies belonged to the Lactobacillus and Bifidobacterium genus. The dosage ranged from 2×107 to 6×1010 CFU/ g. The form of the probiotics varied across the studies (capsules, sachets, soy milk, kefir and honey). The majority of the studies demonstrated the benefits of probiotic supplementation on the reduction of inflammation, oxidative stress and on the amelioration of renal function biomarkers in subjects with diabetic nephropathy. No major gastrointestinal adverse events were observed during the intervention time with probiotics.

Conclusion: Findings of this systematic review demonstrate the positive impact of probiotics on Diabetic Nephropathy without any major adverse events. Moreover, future larger randomized controlled trials with bigger samples and longer follow-up time are deemed necessary for further valid results on the effectiveness of probiotic supplementation on Diabetic Nephropathy.

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Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
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期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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