衰老的生物学和理论。

IF 1.5 4区 生物学 Q4 Agricultural and Biological Sciences Theoretical Biology Forum Pub Date : 2019-01-01 DOI:10.19272/201911402006
Snežana M Stanić, Sanja Lj Matić
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引用次数: 1

摘要

衰老是一种自然的、依赖时间的过程,其特征是分子、细胞、组织和器官发生了不可逆转的变化。它的发生是由于组织的不同层次累积损伤的结果,特别是通过破坏蛋白质和DNA。对于年龄何时、如何产生以及产生的原因,没有单一的定义,也没有唯一的态度。这一过程极其复杂,很可能是不同机制(不仅是遗传的,而且是后天的)影响的结果,这些机制导致体内平衡被破坏,抗逆性降低,疾病发生的频率更高。关于衰老的理论有很多分类,它们经常相互矛盾。没有任何一种理论能够充分解释衰老的过程。本研究的目的是分析衰老的不同方面、主要特征、衰老速度的个体差异以及衰老机制的理论。
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The biology and t heories of aging.

Aging is a natural, time-dependent process characterized by irreversible changes in the molecules, cells, tissues, and organs. It occurs as a result of cumulative damage at different levels of the organization, in particular by damaging proteins and DNA. There is no single definition, nor a unique attitude about when and how age arises and what are its causes. The process is extremely complex and most likely a consequence of the effects of different mechanisms (not only genetic but also acquired) that lead to disrupt homeostasis, reduce stress resistance and the more frequent occurrence of the disease. There are many classifications of theories about aging and they often contradict one another. No one theory is sufficiently able to explain the process of aging. The aim of this work is to analyze the different aspects, main characteristics of the aging, individual differences in the speed of this process and theories about the mechanisms of aging.

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来源期刊
Theoretical Biology Forum
Theoretical Biology Forum 生物-生物学
CiteScore
0.70
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0.00%
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0
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>12 weeks
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