Ning Wang, Boshen Wang, Jiadi Guo, Suhao Zhang, Lei Han, Juan Zhang, Baoli Zhu
{"title":"中国人群中XPO5基因单核苷酸多态性与噪声性听力损失有关","authors":"Ning Wang, Boshen Wang, Jiadi Guo, Suhao Zhang, Lei Han, Juan Zhang, Baoli Zhu","doi":"10.1155/2020/9589310","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p><p><strong>Methods: </strong>We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p><p><strong>Results: </strong>We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5. Conclusion</i>. The genetic polymorphism, rs11077, within <i>XPO5</i> is associated with the risk of noise-induced hearing loss in a Chinese population.<i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p>","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"9589310"},"PeriodicalIF":3.4000,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9589310","citationCount":"4","resultStr":"{\"title\":\"Single-Nucleotide Polymorphisms in <i>XPO5</i> are Associated with Noise-Induced Hearing Loss in a Chinese Population.\",\"authors\":\"Ning Wang, Boshen Wang, Jiadi Guo, Suhao Zhang, Lei Han, Juan Zhang, Baoli Zhu\",\"doi\":\"10.1155/2020/9589310\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p><p><strong>Methods: </strong>We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p><p><strong>Results: </strong>We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on <i>XPO5. Conclusion</i>. The genetic polymorphism, rs11077, within <i>XPO5</i> is associated with the risk of noise-induced hearing loss in a Chinese population.<i>XPO5</i> gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.</p>\",\"PeriodicalId\":8826,\"journal\":{\"name\":\"Biochemistry Research International\",\"volume\":\"2020 \",\"pages\":\"9589310\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2020-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2020/9589310\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry Research International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2020/9589310\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry Research International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/9589310","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population.
Objectives: The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.
Methods: We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.
Results: We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5. Conclusion. The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.
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