自体条件血清:一种新型疾病调节剂治疗膝骨关节炎的临床和功能结果。

IF 2.4 Journal of Drug Assessment Pub Date : 2020-03-25 eCollection Date: 2020-01-01 DOI:10.1080/21556660.2020.1734009
Matteo Vitali, Marco Ometti, Andreas Drossinos, Pierluigi Pironti, Luca Santoleri, Vincenzo Salini
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引用次数: 14

摘要

目的:本研究的目的是探讨自体条件血清(ACS)减轻膝关节骨关节炎(OA)患者疼痛和改善关节功能的潜在能力。方法:选取15例有临床及影像学征象的膝关节OA患者作为研究对象。每位患者接受4次ACS (Orthokine;orthogen,杜塞尔多夫,德国)在OA现场每周一次,持续4周。采用首次注射前、第1周、第2周、第3周、第1个月和第6个月的疼痛VAS评分、WOMAC评分和KSS功能和临床评分进行临床和功能评价。统计学分析采用Wilcoxon sign - rank检验。结果:随访6个月,各项评价指标均有改善。其中,VAS评分下降35.8% (p = 0.00148), KSS功能评分提高38.2% (p = 0.00148), KSS临床评分提高28.9% (p = 0.00236), WOMAC评分降低19.8% (p = 0.00188)。在我们的样本中几乎没有观察到不良反应。最常见的主诉是关节内注射后数日的疼痛和肿胀。只有一名患者报告在注射ACS后出现僵硬。结论:我们的研究结果,结合已有的关于ACS的医学文献研究,证明了这种治疗膝关节OA的可行性,对疼痛和关节功能有积极的影响,没有明显的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Autologous conditioned serum: clinical and functional results using a novel disease modifying agent for the management of knee osteoarthritis.

Objective: The purpose of this study was to investigate the potential ability of autologous conditioned serum (ACS) to decrease pain and improve joint functionality in patients affected by knee osteoarthritis (OA). Methods: Fifteen patients with clinical and radiological signs of OA of the knee were recruited for this study. Each patient received 4 injections of ACS (Orthokine; orthogen, Dusseldorf, Germany) at the site of OA once per week for 4 weeks. Clinical and functional evaluation was performed using the VAS scale for pain, WOMAC scale and KSS functional and clinical scores before the first injection, at one week, at two weeks, at three weeks, at one month and at six months. Statistical analysis was done with the Wilcoxon Signed-Rank Test. Results: Our results show an improvement of all the evaluation scales at 6 months follow-up. Particularly, VAS scales among all patients decreased by 35.8% (p = .00148), KSS functional scores improved by 38.2% (p = .00148), KSS clinical scores improved by 28.9% (p = .00236) and WOMAC scores were reduced by 19.8% (p = .00188). Few adverse effects were observed in our sample. The most common complaint was pain and swelling in the subsequent days after performing the intra-articular injection. Only one patient reported rigidity following the injection of the ACS. Conclusion: Our results, in conjunction with preexisting studies in the medical literature regarding ACS, demonstrate the viability of this therapy for the treatment of knee OA, showing positive influence on pain and joint function without significant adverse effects.

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Journal of Drug Assessment
Journal of Drug Assessment PHARMACOLOGY & PHARMACY-
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