组合科学的文献亮点:固相合成。

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Literature Highlights in Combinatorial Science: Solid-phase Synthesis.
Title: Traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines using polystyrene-supported vinyl selenide. Authors: Sheng, S.-R.;* Xin, Q.; Liu, X.-L.; Sun, W.-K.; Guo, R.; Huang, X. Jiangxi Normal University, China Source: Synthesis 2006, 2293 – 2296. Significance: Vinylselenide resin underwent cycloaddition with nitrile oxides to give isoxazolines. Resin cleavage was achieved either under oxidative or alkylative conditions to give the oxazoline and iodo-isoxazoline respectively.
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Refinement and 3D-QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker. Literature Highlights in Combinatorial Science: Solid-phase Synthesis. Fluorous 2,4-Dichloro-1,3,5-triazine (F-DCT) as Amide Coupling Agent. Fluorous 2,4-Dichloro-1,3,5-triazines (F-DCTs) as Nucleophile Scavengers. Literature Highlights in Combinatorial Science: QSAR Comb. Sci. 9/2005.
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