Curiouser和Curiouser：理解迭代高还原聚酮合酶编程的进展

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00007e

Russell J. Cox

{"title":"Curiouser和Curiouser：理解迭代高还原聚酮合酶编程的进展","authors":"Russell J. Cox","doi":"10.1039/d2np00007e","DOIUrl":null,"url":null,"abstract":"<div><p>Covering: 1996–2022</p><p>Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both <em>in vitro</em> and <em>in vivo</em> experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"40 1","pages":"Pages 9-27"},"PeriodicalIF":10.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/np/d2np00007e?page=search","citationCount":"9","resultStr":"{\"title\":\"Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases\",\"authors\":\"Russell J. Cox\",\"doi\":\"10.1039/d2np00007e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Covering: 1996–2022</p><p>Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both <em>in vitro</em> and <em>in vivo</em> experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.</p></div>\",\"PeriodicalId\":94,\"journal\":{\"name\":\"Natural Product Reports\",\"volume\":\"40 1\",\"pages\":\"Pages 9-27\"},\"PeriodicalIF\":10.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2023/np/d2np00007e?page=search\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Reports\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S026505682300034X\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S026505682300034X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 9

摘要

覆盖范围：1996-2022过去20年的研究已经开始揭示真菌迭代高还原聚酮合成酶是如何编程的。体外和体内实验都揭示了这些系统的组分催化结构域的内在和外在选择性的相互作用。结构生物学已经开始提供hr-PKS的高分辨率结构，这些结构可以作为其工程和重编程的基础，但迄今为止的进展仍处于初级阶段。然而，将目前的理解水平转化为合理地重新设计这些高效系统的能力，以通过生物技术生产重要的生物活性化合物，存在着重大的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

Covering: 1996–2022

Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.