对曼扎明生物合成假说的再认识

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00082b

Alexander T. Piwko , Brian G. Miller , Joel M. Smith

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引用次数: 0

摘要

涵盖范围：截至2023年，海洋环境是一个丰富但富有挑战性的新型疗法来源。曼扎明类生物碱最能说明这些挑战，其具有强大的生物活性、难以获得以及三十多年来一直无法表征的生物合成途径。这篇综述重点介绍了根据当前生物合成知识和代谢先例评估的曼扎明类的假定生物成因途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revisiting the manzamine biosynthetic hypothesis

Covering: up to 2023

The marine environment represents a rich yet challenging source of novel therapeutics. These challenges are best exemplified by the manzamine class of alkaloids, featuring potent bioactivities, difficult procurement, and a biosynthetic pathway that has eluded characterization for over three decades. This review highlights postulated biogenic pathways toward the manzamines, evaluated in terms of current biosynthetic knowledge and metabolic precedent.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.