Jonathan Nsamba, Swaib A Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M Elliott, Emily L Webb
{"title":"出生体重、纯母乳喂养和婴儿期生长对青春期早期脂肪质量和无脂肪质量指数的影响:恩德培母婴研究(EMaBs)队列分析","authors":"Jonathan Nsamba, Swaib A Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M Elliott, Emily L Webb","doi":"10.12688/aasopenres.12947.2","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Ugandan birth cohort. <b>Methods</b>: Data was collected prenatally from pregnant women and prospectively from their resulting live offspring. Data on body composition (fat mass index [FMI] and fat free mass index [FFMI]) was collected from 10- and 11-year olds. Linear regression was used to assess the effect of birth weight, exclusive breastfeeding and infant growth on FMI and FFMI, adjusting for confounders. <b>Results</b>: 177 adolescents with a median age of 10.1 years were included in analysis, with mean FMI 2.9 kg/m <sup>2</sup> (standard deviation (SD) 1.2), mean FFMI 12.8 kg/m <sup>2</sup> (SD 1.4) and mean birth weight 3.2 kg (SD 0.5). 90 (50.9%) were male and 110 (63.2%) were exclusively breastfeeding at six weeks of age. Birth weight was associated with FMI in adolescence (regression coefficient β= 0.66 per kg increase in birth weight, 95% confidence interval (CI) (0.04, 1.29), P=0.02), while exclusive breastfeeding (β= -0.43, 95% CI (-1.06, 0.19), P=0.12), growth 0-6 months (β= 0.24 95% CI (-0.43, 0.92), P=0.48) and growth 6-12 months (β= 0.61, 95% CI (-0.23, 1.46), P=0.11) were not associated with FMI among adolescents. Birth weight (β= 0.91, 95% CI (0.17, 1.65), P=0.01) was associated with FFMI in adolescence. Exclusive breastfeeding (β= 0.17, 95% CI (-0.60, 0.94), P=0.62), growth 0-6 months (β= 0.56, 95% CI (-0.20, 1.33), P= 0.10), and growth 6-12 months (β= -0.02, 95% CI (-1.02, 0.99), P=0.97) were not associated with FFMI. <b>Conclusions:</b> Birth weight predicted body composition parameters in Ugandan early adolescents, however, exclusive breastfeeding at six weeks of age and growth in infancy did not.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"11"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118828/pdf/","citationCount":"4","resultStr":"{\"title\":\"Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort.\",\"authors\":\"Jonathan Nsamba, Swaib A Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M Elliott, Emily L Webb\",\"doi\":\"10.12688/aasopenres.12947.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Ugandan birth cohort. <b>Methods</b>: Data was collected prenatally from pregnant women and prospectively from their resulting live offspring. Data on body composition (fat mass index [FMI] and fat free mass index [FFMI]) was collected from 10- and 11-year olds. Linear regression was used to assess the effect of birth weight, exclusive breastfeeding and infant growth on FMI and FFMI, adjusting for confounders. <b>Results</b>: 177 adolescents with a median age of 10.1 years were included in analysis, with mean FMI 2.9 kg/m <sup>2</sup> (standard deviation (SD) 1.2), mean FFMI 12.8 kg/m <sup>2</sup> (SD 1.4) and mean birth weight 3.2 kg (SD 0.5). 90 (50.9%) were male and 110 (63.2%) were exclusively breastfeeding at six weeks of age. Birth weight was associated with FMI in adolescence (regression coefficient β= 0.66 per kg increase in birth weight, 95% confidence interval (CI) (0.04, 1.29), P=0.02), while exclusive breastfeeding (β= -0.43, 95% CI (-1.06, 0.19), P=0.12), growth 0-6 months (β= 0.24 95% CI (-0.43, 0.92), P=0.48) and growth 6-12 months (β= 0.61, 95% CI (-0.23, 1.46), P=0.11) were not associated with FMI among adolescents. Birth weight (β= 0.91, 95% CI (0.17, 1.65), P=0.01) was associated with FFMI in adolescence. Exclusive breastfeeding (β= 0.17, 95% CI (-0.60, 0.94), P=0.62), growth 0-6 months (β= 0.56, 95% CI (-0.20, 1.33), P= 0.10), and growth 6-12 months (β= -0.02, 95% CI (-1.02, 0.99), P=0.97) were not associated with FFMI. <b>Conclusions:</b> Birth weight predicted body composition parameters in Ugandan early adolescents, however, exclusive breastfeeding at six weeks of age and growth in infancy did not.</p>\",\"PeriodicalId\":34179,\"journal\":{\"name\":\"AAS Open Research\",\"volume\":\" \",\"pages\":\"11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118828/pdf/\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AAS Open Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12688/aasopenres.12947.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Multidisciplinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AAS Open Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/aasopenres.12947.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Multidisciplinary","Score":null,"Total":0}
引用次数: 4
摘要
背景:非洲关于产前和产后生长和婴儿喂养对后期身体成分影响的数据有限。本研究的目的是调查出生体重、纯母乳喂养和婴儿生长对青少年身体组成的影响，使用来自乌干达出生队列的数据。方法:收集孕妇产前的数据，并对其产生的活产儿进行前瞻性的数据收集。收集10岁和11岁儿童的身体组成数据(脂肪质量指数[FMI]和无脂肪质量指数[FFMI])。采用线性回归评估出生体重、纯母乳喂养和婴儿生长对FMI和FFMI的影响，并对混杂因素进行调整。结果:177名中位年龄为10.1岁的青少年纳入分析，平均FMI为2.9 kg/ m2(标准差(SD) 1.2)，平均FFMI为12.8 kg/ m2 (SD 1.4)，平均出生体重为3.2 kg (SD 0.5)。90例(50.9%)为男性，110例(63.2%)为6周龄纯母乳喂养。出生体重与青少年FMI相关(回归系数β= 0.66, 95%可信区间(CI) (0.04, 1.29)， P=0.02)，而纯母乳喂养(β= -0.43, 95% CI (-1.06, 0.19)， P=0.12)，生长0-6个月(β= 0.24, 95% CI (-0.43, 0.92)， P=0.48)和生长6-12个月(β= 0.61, 95% CI (-0.23, 1.46)， P=0.11)与青少年FMI无关。出生体重(β= 0.91, 95% CI (0.17, 1.65)， P=0.01)与青春期FFMI相关。纯母乳喂养(β= 0.17, 95% CI (-0.60, 0.94)， P=0.62)、生长0-6个月(β= 0.56, 95% CI (-0.20, 1.33)， P= 0.10)和生长6-12个月(β= -0.02, 95% CI (-1.02, 0.99)， P=0.97)与FFMI无关。结论:出生体重可以预测乌干达早期青少年的身体组成参数，然而，6周龄时的纯母乳喂养和婴儿期的生长不能预测。
Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort.
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on adolescent body composition, using data from a Ugandan birth cohort. Methods: Data was collected prenatally from pregnant women and prospectively from their resulting live offspring. Data on body composition (fat mass index [FMI] and fat free mass index [FFMI]) was collected from 10- and 11-year olds. Linear regression was used to assess the effect of birth weight, exclusive breastfeeding and infant growth on FMI and FFMI, adjusting for confounders. Results: 177 adolescents with a median age of 10.1 years were included in analysis, with mean FMI 2.9 kg/m 2 (standard deviation (SD) 1.2), mean FFMI 12.8 kg/m 2 (SD 1.4) and mean birth weight 3.2 kg (SD 0.5). 90 (50.9%) were male and 110 (63.2%) were exclusively breastfeeding at six weeks of age. Birth weight was associated with FMI in adolescence (regression coefficient β= 0.66 per kg increase in birth weight, 95% confidence interval (CI) (0.04, 1.29), P=0.02), while exclusive breastfeeding (β= -0.43, 95% CI (-1.06, 0.19), P=0.12), growth 0-6 months (β= 0.24 95% CI (-0.43, 0.92), P=0.48) and growth 6-12 months (β= 0.61, 95% CI (-0.23, 1.46), P=0.11) were not associated with FMI among adolescents. Birth weight (β= 0.91, 95% CI (0.17, 1.65), P=0.01) was associated with FFMI in adolescence. Exclusive breastfeeding (β= 0.17, 95% CI (-0.60, 0.94), P=0.62), growth 0-6 months (β= 0.56, 95% CI (-0.20, 1.33), P= 0.10), and growth 6-12 months (β= -0.02, 95% CI (-1.02, 0.99), P=0.97) were not associated with FFMI. Conclusions: Birth weight predicted body composition parameters in Ugandan early adolescents, however, exclusive breastfeeding at six weeks of age and growth in infancy did not.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
