超重和肥胖妇女体重变化及其与心脏代谢危险标志物的关系

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2020-04-13 eCollection Date: 2020-01-01 DOI:10.1155/2020/3198326
Liyana Ahmad Zamri, Geeta Appannah, Siti Yazmin Zahari Sham, Fazliana Mansor, Rashidah Ambak, Noor Safiza Mohd Nor, Tahir Aris
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引用次数: 4

摘要

目的:研究来自低社会经济地区的超重和肥胖妇女进行生活方式干预时,体重减轻程度与心脏代谢危险标志物变化的关系。方法:对马来西亚巴生谷低社会经济社区完成12个月生活方式干预的243名妇女(平均体重指数31.27±4.14 kg/m2)进行分析。采用协方差分析(ANCOVA)比较不同体重变化类别(增加2%,维持±2%,>2)中心脏代谢危险因素的变化。结果:干预组在干预后6个月观察到不同体重变化类别中腰围、空腹胰岛素和总胆固醇的变化呈分级关联(所有变量p=0.002)。体重减轻5%至20%的参与者在这些风险指标上有最大的改善(-5.67 cm CI: -7.98至-3.36,-4.27 μU/mL CI: -7.35, -1.19和-0.59 mmol/L CI: -)。99,分别为-0.19)。体重减轻>2% (μU/mL CI: -1.95 ~ 1.24)者比体重维持或增加者多。在对照组中,除了腰围和脂联素外,在体重变化类别的风险指标变化中没有发现显著的关联。结论:体重减轻>2 ~ 2
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Weight Change and Its Association with Cardiometabolic Risk Markers in Overweight and Obese Women.

Objectives: To examine the association of weight loss magnitude with changes in cardiometabolic risk markers in overweight and obese women from low socioeconomic areas engaged in a lifestyle intervention.

Methods: Analyses were performed on 243 women (mean body mass index 31.27 ± 4.14 kg/m2) who completed a 12-month lifestyle intervention in low socioeconomic communities in Klang Valley, Malaysia. Analysis of covariance (ANCOVA) was used to compare changes of cardiometabolic risk factors across weight change categories (2% gain, ±2% maintain, >2 to <5% loss, and 5 to 20% loss) within intervention and control group.

Results: A graded association for changes in waist circumference, fasting insulin, and total cholesterol (p=0.002, for all variables) across the weight change categories were observed within the intervention group at six months postintervention. Participants who lost 5 to 20% of weight had the greatest improvements in those risk markers (-5.67 cm CI: -7.98 to -3.36, -4.27 μU/mL CI: -7.35, -1.19, and -0.59 mmol/L CI: -.99, -0.19, respectively) compared to those who did not. Those who lost >2% to <5% weight reduced more waist circumference (-4.24 cm CI: -5.44 to -3.04) and fasting insulin (-0.36 μU/mL CI: -1.95 to 1.24) than those who maintained or gained weight. No significant association was detected in changes of risk markers across the weight change categories within the control group except for waist circumference and adiponectin.

Conclusion: Weight loss of >2 to <5% obtained through lifestyle intervention may represent a reasonable initial weight loss target for women in the low socioeconomic community as it led to improvements in selected risk markers, particularly of diabetes risk.

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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
期刊最新文献
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