基于姜黄的口腔冲洗液“HTOR-091516”改善实验性口腔黏膜炎。

Ayu Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI:10.4103/ayu.AYU_282_18
Suryakanth Dattatreya Anturlikar, Mohammed Mukhram Azeemuddin, Sandeep Varma, Onkaramurthy Mallappa, Dilip Niranjan, Ashok Basti Krishnaiah, Shruthi Manjunath Hegde, Mohamed Rafiq, Rangesh Paramesh
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引用次数: 2

摘要

背景:口腔黏膜炎(OM)的患病率和发病率正在急剧上升,目前尚无有效的治疗方法。对含姜黄、Triphala、蜂蜜的中药制剂HTOR-091516治疗OM的疗效进行了评价。目的:采用细胞模型、人牙龈成纤维细胞-1 (HGF-1)和5-氟尿嘧啶(5-FU)诱导大鼠粘膜炎模型,评价HTOR-091516的安全性和有效性。材料与方法:采用3-(4,5 -二甲基噻唑-2)- 2,5 -二苯基溴化四唑(MTT)法测定细胞活力,采用TNF-α生物测定法测定HTOR-091516对脂多糖诱导的HGF-1的抑制作用。用5-FU和冰醋酸诱导大鼠OM。将动物分为两组,1组作为黏膜炎对照组,2组用200 μl剂量的HTOR-091516治疗,测定血浆样品中TNF-α的含量。结果:HTOR-091516体外安全性在重建的人口腔表皮中进行了评估,发现其无毒且对HGF-1具有浓度依赖性的TNF-α抑制作用。HTOR-091516治疗可降低黏膜炎评分和死亡率,降低血浆TNF-α水平。结论:HTOR-091516治疗OM有较好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Background: Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation "HTOR-091516" containing Curcuma longa, Triphala and honey were evaluated for the treatment of OM.

Aim: The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.

Materials and methods: The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.

Results: The in vitro safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.

Conclusion: The present data indicate that HTOR-091516 is effective in the treatment of OM.

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