成人造血的来源和动态:来自血统追踪的见解。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-24 DOI:10.1146/annurev-cellbio-020520-114601
Joseph N Pucella, Samik Upadhaya, Boris Reizis
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引用次数: 27

摘要

所有血细胞谱系(造血)的产生贯穿于成年哺乳动物的整个生命周期。使用细胞移植的研究确定了自我更新的多能造血干细胞(hsc)作为过继宿主造血的来源,并描绘了最终产生成熟血细胞的hsc衍生祖细胞的等级。然而,由于成人造血发生在原生宿主体内,即不需要移植,因此对成人造血知之甚少。在这里,我们回顾了我们对天然造血的理解的最新进展,特别关注遗传谱系追踪在小鼠中的应用。新出现的证据表明,造血干细胞是天然造血的主要来源,有助于确定造血干细胞分化的动力学,并开始探索衰老和炎症等应激条件下的天然造血。关于天然造血的主要悬而未决的问题仍然存在,例如它的克隆组成,谱系承诺的性质,以及人类造血过程的动力学。
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The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing.

The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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