亚细胞结构的缩放。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-30 DOI:10.1146/annurev-cellbio-020520-113246
Wallace F Marshall
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引用次数: 21

摘要

随着细胞的生长,其内部细胞器的大小和数量会增加,以满足不断增加的代谢需求。细胞器大小异常是癌症的一个标志,也是细胞病理学诊断的一个重要方面。大多数细胞器的大小或数量不同,或者两者都不同,这是细胞大小的函数,但产生这种变化的机制尚不清楚。在某些情况下,细胞器的大小似乎通过相对生长过程与细胞大小成比例,但在另一些情况下,大小可以通过主动测量系统或遗传程序设置,这些程序指示细胞器生物合成活动,以创建适合给定细胞类型的大小的细胞器。
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Scaling of Subcellular Structures.

As cells grow, the size and number of their internal organelles increase in order to keep up with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer and an important aspect of diagnosis in cytopathology. Most organelles vary in either size or number, or both, as a function of cell size, but the mechanisms that create this variation remain unclear. In some cases, organelle size appears to scale with cell size through processes of relative growth, but in others the size may be set by either active measurement systems or genetic programs that instruct organelle biosynthetic activities to create organelles of a size appropriate to a given cell type.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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