奥沙利铂诱导的胃癌Lhermitte征象

IF 0.6 Q4 ONCOLOGY Case Reports in Oncological Medicine Pub Date : 2020-06-24 eCollection Date: 2020-01-01 DOI:10.1155/2020/8826657

Takeshi Okamoto, Koichi Takagi, Katsuyuki Fukuda

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引用次数: 3

摘要

一名64岁的日本男性，无明显病史，出现持续2周的上腹部不适。他被诊断为转移性her2阳性胃癌。化疗开始使用卡培他滨、奥沙利铂和曲妥珠单抗。在第八个周期，他突然抱怨颈部弯曲时双腿有触电样疼痛，与Lhermitte症状一致。停用奥沙利铂，3个月后Lhermitte症状消失。神经毒性在铂基化疗中很常见，但Lhermitte症状很少见。这是在胃癌患者中首次报道奥沙利铂诱导的Lhermitte征象。

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Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer.

A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient.

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Case Reports in Oncological Medicine ONCOLOGY-

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审稿时长

16 weeks

期刊介绍： Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.