全氟和多氟烷基物质与男性生殖健康:流行病学证据的系统审查。

IF 6.4 2区 医学 Q1 ENVIRONMENTAL SCIENCES Journal of Toxicology and Environmental Health-Part B-Critical Reviews Pub Date : 2020-08-17 Epub Date: 2020-08-02 DOI:10.1080/10937404.2020.1798315
Kajsa Ugelvig Petersen, Josefine Rahbæk Larsen, Laura Deen, Esben Meulengracht Flachs, Katia Keglberg Hærvig, Sidsel Dan Hull, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg
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引用次数: 16

摘要

接触环境污染物可能对男性生殖健康造成损害。近年来,评估人类暴露于全氟烷基和多氟烷基物质(PFAS)的潜在后果的流行病学文献越来越多,对产前和产后影响都有关注。本系统综述的目的是评估生命不同阶段PFAS暴露与精液质量、生殖激素、隐睾、尿道下裂和睾丸癌之间的关系。在PubMed和Embase®数据库中系统检索2020年3月9日之前发表的文献。两位作者独立筛选研究记录,采用预定义的资格标准。在文献检索中检索到的242项研究记录中,有26项研究符合定性评价。虽然几项研究表明单一化合物与特定结果之间存在微弱关联,但研究之间缺乏一致性限制了总体证据的结论。目前的知识差距在成年前的暴露,PFAS和其他类型的环境化学物质的组合暴露以及诸如隐睾症、尿道下裂和睾丸癌等结果方面尤其明显。需要通过高质量的流行病学研究,继续努力澄清接触全氟化钠与男性生殖健康之间的关系。
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Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence.

Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures in different stages of life and semen quality, reproductive hormones, cryptorchidism, hypospadias, and testicular cancer. A systematic search of literature published prior to March 9th, 2020, was performed in the databases PubMed and Embase®. Predefined criteria for eligibility were applied by two authors screening study records independently. Among the 242 study records retrieved in the literature search, 26 studies were eligible for qualitative assessment. While several investigations suggested weak associations for single compounds and specific outcomes, a lack of consistency across studies limited conclusions of overall evidence. The current gap in knowledge is particularly obvious regarding exposures prior to adulthood, exposure to combinations of both PFAS and other types of environmental chemicals, and outcomes such as cryptorchidism, hypospadias, and testicular cancer. Continued efforts to clarify associations between PFAS exposure and male reproductive health through high-quality epidemiological studies are needed.

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来源期刊
CiteScore
13.80
自引率
6.90%
发文量
13
审稿时长
>24 weeks
期刊介绍: "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.
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