Kajsa Ugelvig Petersen, Josefine Rahbæk Larsen, Laura Deen, Esben Meulengracht Flachs, Katia Keglberg Hærvig, Sidsel Dan Hull, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg
{"title":"全氟和多氟烷基物质与男性生殖健康:流行病学证据的系统审查。","authors":"Kajsa Ugelvig Petersen, Josefine Rahbæk Larsen, Laura Deen, Esben Meulengracht Flachs, Katia Keglberg Hærvig, Sidsel Dan Hull, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg","doi":"10.1080/10937404.2020.1798315","DOIUrl":null,"url":null,"abstract":"<p><p>Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures in different stages of life and semen quality, reproductive hormones, cryptorchidism, hypospadias, and testicular cancer. A systematic search of literature published prior to March 9th, 2020, was performed in the databases PubMed and Embase®. Predefined criteria for eligibility were applied by two authors screening study records independently. Among the 242 study records retrieved in the literature search, 26 studies were eligible for qualitative assessment. While several investigations suggested weak associations for single compounds and specific outcomes, a lack of consistency across studies limited conclusions of overall evidence. The current gap in knowledge is particularly obvious regarding exposures prior to adulthood, exposure to combinations of both PFAS and other types of environmental chemicals, and outcomes such as cryptorchidism, hypospadias, and testicular cancer. Continued efforts to clarify associations between PFAS exposure and male reproductive health through high-quality epidemiological studies are needed.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":null,"pages":null},"PeriodicalIF":6.4000,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10937404.2020.1798315","citationCount":"16","resultStr":"{\"title\":\"Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence.\",\"authors\":\"Kajsa Ugelvig Petersen, Josefine Rahbæk Larsen, Laura Deen, Esben Meulengracht Flachs, Katia Keglberg Hærvig, Sidsel Dan Hull, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg\",\"doi\":\"10.1080/10937404.2020.1798315\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Exposure to environmental pollutants may produce impairment of male reproductive health. 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Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence.
Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures in different stages of life and semen quality, reproductive hormones, cryptorchidism, hypospadias, and testicular cancer. A systematic search of literature published prior to March 9th, 2020, was performed in the databases PubMed and Embase®. Predefined criteria for eligibility were applied by two authors screening study records independently. Among the 242 study records retrieved in the literature search, 26 studies were eligible for qualitative assessment. While several investigations suggested weak associations for single compounds and specific outcomes, a lack of consistency across studies limited conclusions of overall evidence. The current gap in knowledge is particularly obvious regarding exposures prior to adulthood, exposure to combinations of both PFAS and other types of environmental chemicals, and outcomes such as cryptorchidism, hypospadias, and testicular cancer. Continued efforts to clarify associations between PFAS exposure and male reproductive health through high-quality epidemiological studies are needed.
期刊介绍:
"Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health.
Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews."
The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.