一种新型人工真皮层作为面部和头皮皮肤癌重建的成功工具:疗效、安全性和美学结果分析。

IF 1.5 Q3 DERMATOLOGY Dermatology Research and Practice Pub Date : 2020-07-20 eCollection Date: 2020-01-01 DOI:10.1155/2020/4874035
Fedele Lembo, Liberato Roberto Cecchino, Domenico Parisi, Aurelio Portincasa
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引用次数: 8

摘要

根治性消融手术是治疗头部皮肤癌的金标准。作者揭示了他们的经验与新的人工真皮(Pelnac®),回顾性分析总体发病率和美学结果。16例患者在局部麻醉下连续进行了两次手术。第一种方法是切除肿瘤并应用adm。第二种方法是在暴露的组织上覆盖裂厚的皮肤移植物。在随访(6个月)中,评估肿瘤复发、疤痕质量(使用温哥华疤痕量表)和患者报告的结果(使用FACE-Q皮肤癌模块)。男性10例,女性6例,平均年龄73岁(61 ~ 89岁)。随访12 ~ 48个月(平均30个月)。皮肤肿瘤部位为头皮(12例)、前额(2例)、脸颊(1例)、颧骨(1例)。既往局部手术9例;2例接受放疗。平均住院时间为3.2天。缺损的平均表面积为59.15 cm2(16.9 ~ 89.5)。3例手术床为无骨膜骨。恶性肿瘤为基底细胞癌(68.75%)、鳞状细胞癌(18.75%)、恶性黑色素瘤(6.25%)、肉瘤(6.25%)。第一次手术(25-55分钟)平均手术时间41分钟,第二次手术(25-48分钟)平均手术时间34分钟。无明显问题,15例(93.75%)患者的移植物摄入量达到100%。平均愈合时间39天(32 ~ 45天)。术后6个月,肿瘤未复发。VSS量表和FACEQ皮肤癌模块平均评分显示,所有患者均获得满意的美容和功能结果。我们相信人工真皮层是一种可靠的替代皮瓣,应该被认为是皮肤癌头部重建的一个很好的选择,特别是对于危重患者(年老,有大而深的缺陷,肿瘤复发,需要放疗)。
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Utility of a New Artificial Dermis as a Successful Tool in Face and Scalp Reconstruction for Skin Cancer: Analysis of the Efficacy, Safety, and Aesthetic Outcomes.

Radical ablative surgery is the gold standard treatment of head skin cancer. The authors expose their experience with a new artificial dermis (Pelnac®), analyzing retrospectively the overall morbidity and aesthetic outcomes. 16 consecutive patients underwent two surgical procedures under local anesthesia. The first involved the tumor removal and application of the ADM. In the second, the exposed tissue was covered with a split-thickness skin graft. On follow-up (6 months), tumor recurrences, quality of scars (using the Vancouver Scar Scale), and patient reported outcomes (using FACE-Q Skin Cancer Module) were evaluated. 10 were males and 6 females, with a mean age of 73 years (61-89). The follow-up ranged from 12 to 48 months (mean: 30). The sites of skin tumor were scalp (12 cases), forehead (2), cheek (1), and zygomatic area (1). Nine patients underwent previous local surgery; two received radiotherapy. The average length of hospital stay was 3.2 days. The mean surface area of the defect was 59.15 cm2 (16.9-89.5). In three cases, the surgical bed was bone without periosteum. The malignant tumors excised were basal cell carcinoma (68.75%), squamous cell carcinoma (18.75%), malignant melanoma (6.25%), and sarcoma (6.25%). The mean operating time was 41 minutes for the first operation (25-55) and 34 for the second (25-48). No significant problems were observed and 15 patients (93.75%) had 100 percent intake of graft. The mean time of healing was 39 days (32-45). At 6 months post-op, no tumor recurrence. Satisfactory cosmetic and functional results were obtained in all patients as shown by the VSS Scale and FACEQ skin cancer module mean scores. We believe that the artificial dermis is a reliable alternative to flaps and should be considered an excellent option in head reconstruction for skin cancer, especially in critical patients (old, with large and deep defects, with recurrent tumors, required radiotherapy).

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
16
审稿时长
11 weeks
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