新的靶点:来源于M2巨噬细胞的外泌体。

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-08-12 DOI:10.1080/08830185.2020.1800687
Yuyang Hou, Yuntong Liu, Shu Liang, Ru Ding, Shuqian Mo, Dongmei Yan, Dong Li
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引用次数: 10

摘要

随着纳米技术和精准医学的进步,越来越多的基于外泌体的治疗方法被开发出来。外泌体是一种具有双层磷脂的微小囊泡,可以将生物大分子传递给受体,从而影响生物过程。M2巨噬细胞与肿瘤等重大疾病的发生发展密切相关。除了巨噬细胞的活化、分泌细胞因子等可溶性因子等传统功能概念外,最近有研究发现M2巨噬细胞衍生的外泌体通过携带microRNA、long noncodingRNA和功能蛋白调控靶基因表达及相关蛋白合成,从而影响疾病的发展。在这里,我们概述了外泌体的生物发生及其在疾病中的生物学功能。然后,我们重点阐明了来自M2巨噬细胞的外泌体在几种疾病中的作用及其机制。最后,我们讨论了基于外泌体和巨噬细胞的现有潜在应用的适当性和不适当性。
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The novel target:exosoms derived from M2 macrophage.

More and more exosome-based therapeutics are being developed with advances in nanotechnology and precision medicine. Exosome is a kind of tiny vesicles with a bilayer of phospholipids, which can transfer biological macromolecules to recipients to influence the biological process. M2 macrophages are closely related to the occurrence and development of serious diseases such as tumor. In addition to the traditional concept of macrophage functions such as opsonization, secretion of cytokines and other soluble factors, some studies have found that the exosome derived from M2 macrophages can influence the development of disease by carrying microRNA, long noncodingRNA and functional proteins to regulate target gene expression as well as related proteins synthesis recently. Here, we outlined the biogenesis of the exosome and its biological functions in disease. Then we focused on elucidating the effects of the exosome derived from M2 macrophages on several diseases and its mechanisms. Finally, we discussed the appropriateness and inappropriateness in existing potential applications based on exosomes and macrophages.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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