连续性原理与复制保真度的演化

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2020-11-29 DOI:10.1007/s10441-020-09399-4
Seymour Garte
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引用次数: 3

摘要

现代生活的进化需要高复制保真度,以允许自然选择。利用细胞生存概率的模拟表型数据开发了一个模拟模型,以确定自我复制保真度如何在生命早期进化。结果表明,初始生存能力和复制保真度都有助于整体适应度,通过细胞群体的生长率来衡量。生存概率是更主要的特征,即使复制保真度为零,进化也是可能的。导出的生存概率和复制保真度与生长速率的关系公式与模拟的经验数据一致。对连续性和其他证据的定量评估获得了跳跃式(非连续)进化过程,从低到中等水平的生存概率和自我复制保真度开始,达到现代生命形式中所见的高水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Continuity Principle and the Evolution of Replication Fidelity

Evolution in modern life requires high replication fidelity to allow for natural selection. A simulation model utilizing simulated phenotype data on cellular probability of survival was developed to determine how self-replication fidelity could evolve in early life. The results indicate that initial survivability and replication fidelity both contribute to overall fitness as measured by growth rates of the cell population. Survival probability was the more dominant feature, and evolution was possible even with zero replication fidelity. A derived formula for the relationship of survival probability and replication fidelity with growth rate was consistent with the simulated empirical data. Quantitative assessment of continuity and other evidence was obtained for a saltation (non-continuous) evolutionary process starting from low to moderate levels of survival probability and self-replication fidelity to reach the high levels seen in modern life forms.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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