外表皮皮炎是婴儿中央线相关血流感染的原因:病例报告和文献回顾

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI:10.1016/j.riam.2020.09.004

Anil Kumar , Aswathy Nandakumar , Sajitha Nair , Ashutosh Singh , Nandita Shashindran , Swathy Thulasidharan , Kiran Subhash , Arya Ramachandran , Anuradha Chowdhary

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引用次数: 6

摘要

背景:嗜皮菌性皮炎是一种真菌，已知可引起浅表、皮下、皮肤和深部感染，很少引起中枢性血流感染(CLABSI)。一例CLABSI由于在一个婴儿皮炎e描述。病例报告:临床和实验室资料摘自患者病历和实验室记录。通过表型鉴定和核糖体DNA ITS区和LSU区测序，鉴定该分离物为皮炎杆菌。Medline检索回顾了所有由皮炎E.引起的CLABSI病例。与氟康唑(4 mg/l)相比，泊沙康唑(0.06 mg/l)、伏立康唑(0.03 mg/l)和伊曲康唑(0.03 mg/l)的mic值非常低。结论文献中未见婴儿皮炎e型所致CLABSI病例，本文报道第一例。测序是准确鉴定该物种的必要方法。迅速切除中央静脉导管，然后用两性霉素B或唑治疗，似乎是最有效的治疗方法。

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Exophiala dermatitidis as a cause of central line associated bloodstream infection in an infant: Case report and literature review

Background

Exophiala dermatitidis is a dematiaceous fungus known to cause superficial, subcutaneous, cutaneous and deep seated infections, and rarely central line associated bloodstream infection (CLABSI). A case of CLABSI due to E. dermatitidis in an infant is described.

Case report

Clinical and laboratory data were extracted from patient's chart and laboratory records. The isolate was identified as E. dermatitidis by phenotypic characterization and sequencing of the ITS and LSU regions of the ribosomal DNA. Medline search was done to review all cases of CLABSI due to E. dermatitidis. Among the azoles tested, posaconazole (0.06 mg/l), voriconazole (0.03 mg/l) and itraconazole (0.03 mg/l) showed very low MICs when compared to fluconazole (4 mg/l)

Conclusions

As we did not found in the literature any case of CLABSI due to E. dermatitidis in an infant, we report the first one. Sequencing is a mandatory method for accurately identifying this species. Prompt removal of the central line, followed by a treatment with amphotericin B or an azole, seems to be the most effective treatment.

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.