Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves
{"title":"与获得性免疫缺陷综合征相关的巴西副球虫S1引起的副球虫菌病:1例报告","authors":"Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves","doi":"10.1016/j.riam.2020.09.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms.</p></div><div><h3>Case report</h3><p>We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as <span><em>Paracoccidioides</em><em> brasiliensis</em></span> S1 by species-specific PCR using primers for protein-coding gene <em>GP43</em> (exon 2) followed by PCR-RFLP of the alpha-tubulin gene.</p></div><div><h3>Conclusions</h3><p>There are few data in literature reporting species-specific molecular identification of <em>Paracoccidioides</em> in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"38 1","pages":"Pages 5-8"},"PeriodicalIF":1.5000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2020.09.003","citationCount":"3","resultStr":"{\"title\":\"Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report\",\"authors\":\"Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves\",\"doi\":\"10.1016/j.riam.2020.09.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. 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Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report
Background
Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms.
Case report
We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as Paracoccidioides brasiliensis S1 by species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed by PCR-RFLP of the alpha-tubulin gene.
Conclusions
There are few data in literature reporting species-specific molecular identification of Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients.
期刊介绍：
Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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