黄花蒿是一种具有强大伤口愈合功能的药用植物。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2020-09-01 Epub Date: 2020-09-28 DOI:10.1007/s40204-020-00138-z
Fatemeh Sadat Mirbehbahani, Fatemeh Hejazi, Najmeh Najmoddin, Azadeh Asefnejad
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引用次数: 0

摘要

首次将黄花蒿用于纳米纤维伤口敷料成分中。这种珍贵植物的提取物具有抗炎、抗菌和抗微生物的特性,可被视为治疗应用中一种很有前景的药用成分。本研究从伊朗北部戈尔甘森林地区采集了黄花蒿,并以甲醇为提取溶剂制备了黄花蒿提取物。在制作伤口敷料时,将黄花蒿提取物与明胶混合,通过电纺技术形成纳米纤维结构。为了使伤口敷料具有可接受的稳定性和最佳的机械性能,这种生物活性层是在 PCL 纳米纤维基底层上形成的。对制成的双层伤口敷料进行了化学、结构、机械和生物分析。制备的伤口敷料的 ATR-FTIR 光谱含有黄花蒿的官能团,如过氧化物基团等。电纺丝明胶/黄花蒿的扫描电镜显微照片证实,电纺丝工艺成功制备了含黄花蒿的纳米纤维,其平均直径为 242.00 ± 67.53 nm。对制造的伤口敷料进行的体外青蒿释放研究表明,交联样品可持续释放 7 天。此外,对所制备伤口敷料体外结构稳定性的评估证实了交联纳米纤维结构在 PBS 溶液环境中的稳定性。对含有黄花蒿的伤口敷料进行的生物学研究表明,这种敷料没有细胞毒性,能很好地增殖和附着成纤维细胞,对金黄色葡萄球菌具有可接受的抗菌特性。
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Artemisia annua L. as a promising medicinal plant for powerful wound healing applications.

Artemisia annua L. has been utilized for the first time in a nanofibrous wound dressing composition. The extract of this valuable plant provides anti-inflammatory, anti-bacterial and anti-microbial properties which can be considered as a promising medicinal component in therapeutic applications. In the present work, Artemisia annua L. was picked up from Gorgan forest area of Northern Iran and its extract was prepared by methanol as the extraction solvent. In the fabrication of wound dressing, Artemisia annua L. extract was mixed with gelatin and a nanofibrous structure was formed by electrospinning technique. To have a wound dressing with acceptable stability and optimum mechanical properties, this biologically active layer was formed on a PCL nanofibrous base layer. The fabricated double-layer wound dressing was analyzed chemically, structurally, mechanically and biologically. ATR-FTIR spectra of the prepared wound dressing contain functional groups of Artemisia annua L. as peroxide groups, etc. SEM micrographs of electrospun gelatin/Artemisia annua L. confirmed the successful electrospinning process for producing Artemisia annua L.-containing nanofibers with mean diameter of 242.00 ± 67.53 nm. In vitro Artemisia annua L. release study of the fabricated wound dressings suggests a sustain release over 7 days for the crosslinked sample. In addition, evaluation of the in vitro structural stability of the prepared wound dressings confirmed the stability of the crosslinked nanofibrous structures in PBS solution environment. Biological study of the Artemisia annua L.-containing wound dressing revealed no cytotoxicity, good proliferation and attachment of the seeded fibroblasts cells and acceptable antibacterial property against Staphylococcus aureus bacteria.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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