毛细血管前期肺动脉高压患者n端前脑利钠肽水平与心肺运动试验的相关性:一项初步研究

IF 1 Q4 RESPIRATORY SYSTEM Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2020-10-13 eCollection Date: 2020-01-01 DOI:10.1177/1179548420954049
Sahachat Aueyingsak, Wilaiwan Khrisanapant, Upa Kukongviriyapun, Orapin Pasurivong, Pailin Ratanawatkul, Chinadol Wanitpongpan, Burabha Pussadhamma
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引用次数: 1

摘要

背景:n端脑利钠肽前体(NT-proBNP)和心肺运动试验(CPET)可用于评估肺动脉高压(PH)患者的严重程度。这些检测在毛细血管前PH患者中的相关性研究较少。方法:我们研究了23例毛细血管前PH: 8例特发性肺动脉高压(IPAH), 6例系统性硬化症相关性肺动脉高压(SSc-PAH), 9例慢性血栓栓塞性肺动脉高压(CTEPH)。临床评价、NT-proBNP水平、6分钟步行试验(6MWT)、肺活量测定和CPET在同一天进行评估。研究NT-proBNP水平与CPET参数的相关性。结果:在所有患者中,NT-proBNP水平与峰值摄氧量(VO2) (r = -0.47)、峰值氧脉冲(r = -0.43)、峰值心输出量(CO) (r = -0.57)、峰值潮末二氧化碳分压(PETCO2) (r = -0.74)、呼吸当量二氧化碳(VE/VCO2)在无氧阈值(at) (r = 0.73)和VE/VCO2斜率(r = 0.64)显著相关。在IPAH和CTEPH亚组中NT-proBNP水平与PETCO2峰值和VE/VCO2显著相关,在CTEPH亚组中NT-proBNP水平与at时VO2显著相关。SSc-PAH亚组无明显相关性。结论:IPAH和CTEPH亚组患者NT-proBNP水平与CPET参数有显著相关性,SSc-PAH亚组无显著相关性。需要对更大的人群进行进一步的研究来证实这些初步发现。
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Correlation Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Cardiopulmonary Exercise Testing in Patients With Pre-Capillary Pulmonary Hypertension: A Pilot Study.

Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiopulmonary exercise testing (CPET) are useful for severity assessment in patients with pulmonary hypertension (PH). Correlations between these tests in pre-capillary PH patients is less well studied.

Methods: We studied 23 patients with pre-capillary PH: 8 with idiopathic pulmonary arterial hypertension (IPAH), 6 with systemic sclerosis-associated PAH (SSc-PAH), and 9 with chronic thromboembolic pulmonary hypertension (CTEPH). Clinical evaluation, NT-proBNP levels, six-minute walking test (6MWT), spirometry, and CPET were evaluated on the same day. Correlation between NT-proBNP levels and CPET parameters were investigated.

Results: In all patients, NT-proBNP levels were significantly correlated with peak oxygen uptake (VO2) (r = -0.47), peak oxygen pulse (r = -0.43), peak cardiac output (CO) (r = -0.57), peak end-tidal partial pressure of carbon dioxide (PETCO2) (r = -0.74), ventilatory equivalent to carbon dioxide (VE/VCO2) at anaerobic threshold (AT) (r = 0.73), and VE/VCO2 slope (r = 0.64). Significant correlations between NT-proBNP levels and peak PETCO2 and VE/VCO2 were found in IPAH and CTEPH subgroups, and a significant correlation between NT-proBNP levels and VO2 at AT was found in the CTEPH subgroup. No significant correlation was found in the SSc-PAH subgroup.

Conclusion: NT-proBNP levels were significantly correlated with CPET parameters in patients with IPAH and CTEPH subgroups, but not in SSc-PAH subgroup. A further study with larger population is required to confirm these preliminary findings.

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CiteScore
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自引率
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发文量
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审稿时长
8 weeks
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