控制减肥手术后超重的药物的有效性和安全性:系统的文献综述。

IF 2.4 Journal of Drug Assessment Pub Date : 2019-10-17 eCollection Date: 2019-01-01 DOI:10.1080/21556660.2019.1678478
Sean Wharton, Elham Kamran, Mahnoor Muqeem, Amina Khan, Rebecca A G Christensen
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引用次数: 3

摘要

目的:系统回顾有关减肥手术患者体重管理用药的文献。方法:检索自成立至2018年12月31日(含12月31日)的Google Scholar、Pubmed、Cochrane、Embase、Web of Science和Clinical Trials。结果:13项研究符合纳入标准,并报道在减肥手术后患者使用体重管理药物后体重下降。五项研究通过减肥手术类型检查了减肥结果,其中四项研究发现,与使用roux-en-y旁路手术(n = 3篇论文)和可调节胃束带(n = 1篇论文)的患者相比,接受胃套管手术的患者体重减轻较少。四项研究比较了体重管理药物的有效性,并观察到与其他减肥药相比,托吡酯和芬特明作为单一疗法的减重效果略好。使用参与者的子样本,作者观察到二甲双胍的体重减轻较少,而非芬特明或托吡酯对年轻人没有效果。另一项针对同一样本的事后分析发现,服用1.8毫克利拉鲁肽的老年人体重减轻更大。七项研究报告了副作用,总体上与之前在非手术人群中报道的副作用一致。结论:本系统综述的结果表明,药物治疗可能是一种有效的工具,作为饮食和体育活动的辅助,以支持减肥手术后患者的体重减轻。然而,由于大多数研究缺乏对照或安慰剂组,需要更严格的研究来确定这种干预的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The effectiveness and safety of pharmaceuticals to manage excess weight post-bariatric surgery: a systematic literature review.

Objective: To systematically review the literature on weight management pharmaceutical use in patients who have had bariatric surgery. Methods: Google Scholar, Pubmed, Cochrane, Embase, Web of Science, and Clinical Trials were searched from inception to December 31st, 2018 inclusive. Results: Thirteen studies met inclusion and reported decreases in weight with the use of weight management medications in post-bariatric surgical patients. Five studies examined weight loss outcomes by the type of bariatric surgery procedure, and four of these studies observed less weight loss in patients who had undergone gastric sleeve compared to those who had roux-en-y bypass (n = 3 papers) and adjustable gastric banding (n = 1 paper) with medication use. Four studies compared the effectiveness of medications for weight management and observed slightly greater weight loss with the use of topiramate and phentermine as a monotherapy compared to other weight loss medications. Using a sub-sample of participants, authors observed less weight loss on metformin but not phentermine or topiramate for younger adults. Another post-hoc analysis in the same sample observed greater weight loss for older adults with liraglutide 1.8 mg. Side effects were reported in seven studies and were overall consistent with those previously reported in non-surgical populations. Conclusion: Results of this systematic review suggest pharmacotherapy may be an effective tool as an adjunct to diet and physical activity to support weight loss in post-bariatric surgery patients. However, due to most studies lacking a control or placebo group, more rigorous research is required to determine the efficacy of this intervention.

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来源期刊
Journal of Drug Assessment
Journal of Drug Assessment PHARMACOLOGY & PHARMACY-
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