母亲环境暴露于双酚类物质和婴儿脐带血表观基因组DNA甲基化。

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2020-12-23 eCollection Date: 2020-01-01 DOI:10.1093/eep/dvaa021
Carolyn F McCabe, Vasantha Padmanabhan, Dana C Dolinoy, Steven E Domino, Tamara R Jones, Kelly M Bakulski, Jaclyn M Goodrich
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引用次数: 16

摘要

母亲产前暴露,包括双酚A (BPA),与后代以后的疾病风险有关。DNA甲基化的改变可能是一种机制,通过这种机制,产前条件的改变(例如,母亲暴露于环境毒物)引发这种疾病风险。在密歇根母婴队列研究中,研究人员检测了孕妇妊娠早期尿液中BPA、双酚F和双酚S浓度与婴儿脐带血白细胞DNA甲基化模式的关系(N = 69)。我们使用Illumina Infinium MethylationEPIC珠片定量评估整个表观基因组的DNA甲基化;822020探针通过了预处理和质量检查。单位点DNA甲基化和双酚模型根据婴儿性别、估计的细胞类型比例(使用细胞类型估计算法确定)和批次作为协变量进行调整。38个CpG站点[错误发现率(FDR)]
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood.

Maternal prenatal exposures, including bisphenol A (BPA), are associated with offspring's risk of disease later in life. Alterations in DNA methylation may be a mechanism through which altered prenatal conditions (e.g. maternal exposure to environmental toxicants) elicit this disease risk. In the Michigan Mother and Infant Pairs Cohort, maternal first-trimester urinary BPA, bisphenol F, and bisphenol S concentrations were tested for association with DNA methylation patterns in infant umbilical cord blood leukocytes (N = 69). We used the Illumina Infinium MethylationEPIC BeadChip to quantitatively evaluate DNA methylation across the epigenome; 822 020 probes passed pre-processing and quality checks. Single-site DNA methylation and bisphenol models were adjusted for infant sex, estimated cell-type proportions (determined using cell-type estimation algorithm), and batch as covariates. Thirty-eight CpG sites [false discovery rate (FDR) <0.05] were significantly associated with maternal BPA exposure. Increasing BPA concentrations were associated with lower DNA methylation at 87% of significant sites. BPA exposure associated DNA methylation sites were enriched for 38 pathways significant at FDR <0.05. The pathway or gene-set with the greatest odds of enrichment for differential methylation (FDR <0.05) was type I interferon receptor binding. This study provides a novel understanding of fetal response to maternal bisphenol exposure through epigenetic change.

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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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