大量西酞普兰过量与复发性癫痫发作和双侧肩关节脱位有关。

IF 0.8 Q4 PHARMACOLOGY & PHARMACY Journal of Research in Pharmacy Practice Pub Date : 2020-10-08 eCollection Date: 2020-07-01 DOI:10.4103/jrpp.JRPP_20_24
Shafeajafar Zoofaghari, Anselm Wong, Pegah Kiarasi, Farzad Gheshlaghi
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引用次数: 1

摘要

选择性血清素再摄取抑制剂(SSRIs)被广泛用于治疗多种类型的精神障碍。在这方面,西酞普兰通常被用作新一代ssri类药物;然而,不幸的是,它的过量与癫痫发作和心脏疾病有关。本研究报告的病例表现为反复发作,非特异性ST-T改变,过度使用西酞普兰导致QT间期延长。患者在癫痫发作时发生双侧肩前脱位并右侧肱骨近端骨折。脱位先复位后固定。此外,地西泮控制癫痫发作,无任何问题,心脏监测持续2天。大量西酞普兰过量可能与反复发作和QT间期延长有关。癫痫发作后的并发症,如肩部脱位,应检查并适当处理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations.

Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately.

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来源期刊
Journal of Research in Pharmacy Practice
Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
8
审稿时长
21 weeks
期刊介绍: The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
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