基于蛋白质的纳米平台,可通过非侵入性粘膜途径检测结肠中的肿瘤性息肉。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2021-01-20 DOI:10.4155/ppa-2020-0034
Chun-Chieh Chen, Mo A Baikoghli, R Holland Cheng
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引用次数: 0

摘要

随着纳米医学的快速发展,使用纳米颗粒系统诊断和治疗肿瘤的势头越来越猛。许多纳米otheranostics由于生物利用度不足和在肿瘤部位的蓄积量低而失败,从而导致不良副作用。我们介绍了一种工程化戊型肝炎病毒纳米粒子(HEVNP)的使用情况,它具有更强的生物利用度、组织保留和粘膜穿透能力。HEVNP 是一种模块化纳米胶囊,可封装异源核苷酸、蛋白质和无机金属,如氧化亚铁纳米粒子。此外,HEVNP 的外部突出臂由环形结构组成,可用于靶向肽和治疗肽的化学耦合。我们建议使用 HEVNP 靶向结肠直肠癌(即息肉),并利用结肠镜在成像引导下输送。
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Protein-based nanoplatform for detection of tumorigenic polyps in the colon via noninvasive mucosal routes.

The use of nanoparticulate systems to diagnose and treat tumors has gained momentum with the rapid development of nanomedicine. Many nanotheranostics fail due to insufficient bioavailability and low accumulation at the tumor site, resulting in undesirable side effects. We describe the use of an engineered hepatitis E viral nanoparticle (HEVNP) with enhanced bioavailability, tissue retention and mucosal penetration capacities. HEVNP is a modular nanocapsule that can encapsulate heterologous nucleotides, proteins and inorganic metals, such as ferrite oxide nanoparticles. Additionally, the exterior protruding arms of HEVNP is composed of loops that are used for chemical coupling of targeting and therapeutic peptides. We propose the use of HEVNP to target colorectal cancer (i.e., polyps) with imaging-guided delivery using colonoscopy.

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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
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发文量
22
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