Effect of Brihatyadi Yapana Basti and Shivalingi (Bryonia laciniosa Linn.) seed powder in the management of female infertility (Vandhyatva) due to anovulatory factor: An open-labelled randomized clinical trial.

Back ground: Infertility is a global problem that has impact on quality of life, especially through the negative psycho-social consequences. One-third of infertile population attending infertility clinics are reported with anovulation. According to Acharya Sushruta, among four essential factors required for conception, Beeja (ovum) is the core stone of the female reproductive process and conception can not be achieved in its absence, despite of other factors.

Aims and objectives: To evaluate and compare the efficacy of Brihatyadi Yapana Basti (therapeutic enema) and Shivalingi (Bryonia laciniosa Linn) seed powder in the management of female infertility w.s.r to the anovulatory factor.

Materials and methods: Total 30 female patients suffering from infertility due to anovulation confirmed by trans vaginal sonography were enrolled in the present study and randomly divided in two groups i.e., in group A (n = 15), Brihatyadi Yapana Basti (400 ml) was administered for 15 days after menstruation for 2 consecutive cycles. In group B (n = 15) Shivalingi seed powder was administered in dose of 3 gms twice in a day with cow milk on empty stomach for 2 months with 2 months followup. The efficacy of the therapy was assessed on the basis of follicular study by trans-vaginal sonography (TVS) on the 12^th , 14^th, 16^th and 18^th days of menstrual cycle and/or on the basis of conception achieved. The obtained data was analyzed for statistical significance using Student's t-test.

Result: In the Brihatyadi Yapana Basti group, ovulation was found in 80% of the patients and conception rate was 26.66% and in the Shivalingi seed powder oral group, ovulation was found in 64.28% patients and conception was not reported.

Conclusion: It was concluded that Brihatyadi Yapana Basti is more effective in follicular growth, ovulation and also achieving conception than that of Shivalingi seed powder orally.