肢端肥大症患者糖耐量异常的患病率、预测因素及其解决:90例单中心回顾性研究

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2021-08-01 DOI:10.1016/j.ghir.2021.101394
Suhas S. Khaire, Jugal V. Gada, Premlata K. Varthakavi, Nikhil M. Bhagwat
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引用次数: 1

摘要

目的本研究的目的是评估肢端肥大症患者糖耐量异常(糖尿病+前驱糖尿病)的患病率和预测因素及其解决方法。背景和设计回顾性观察性研究。方法和材料选取90例肢端肥大症患者,术后随访1年。研究队列分为两组:A组:糖耐量异常[AGT:糖尿病+前驱糖尿病(n = 40)], B组:糖耐量正常(NGT) (n = 50)。以下参数:年龄、性别、腰围(WC)、体重指数(BMI)、肢端肥大症持续时间、生长激素(GH)水平、胰岛素样生长因子1 (IGF1)水平、垂体瘤大小、高血压和糖尿病家族史作为糖尿病的预测因素,在术前和术后3个月和1年对血糖的影响进行了研究。采用非配对t检验、卡方检验和二元logistic回归分析进行统计分析。结果AGT患病率为44.44%(糖尿病37.77%,糖尿病前期6.66%)。AGT患者年龄较大(44.2±12.21岁∶34.92±11.62岁;p = 0.00040)和较高的WC(单位cm)(91.35±7.87 vs.87.12±6.07;p = 0.005)。高血压和糖尿病家族史在AGT患者中更为常见。各组间GH和IGF1水平无显著差异。二元logistic回归分析发现,性别(p = 0.0105) (OR = 6.0985)、腰围(p = 0.0023) (OR = 1.2276)和高血压(p = 0.0236) (OR = 1.632)是肢端肥大症患者AGT的显著预测因素。术后3个月和1年分别有42.5%和62.5%的患者血糖恢复正常。在二元logistic回归中,没有预测因子能在3个月或1年内达到正常血糖,但是GH、BMI和肿瘤大小的变化是显著的。结论AGT患病率为44.44%。女性、WC和高血压是肢端肥大症患者AGT的重要预测因素。术后3个月和1年的血糖正常率分别为42.5%和62.5%,没有预测AGT正常化的指标。
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Prevalence and predictors of abnormal glucose tolerance and its resolution in acromegaly: Single Centre retrospective study of 90 cases

Aims

The aim of the study was to evaluate the prevalence and predictors of abnormal glucose tolerance (Diabetes + Prediabetes) and its resolution in Acromegaly.

Settings and design

Retrospective observational study.

Methods and material

Ninety patients with acromegaly and followed up post operatively for 1 year were included. The study cohort was divided into two groups: Group A: abnormal glucose tolerance [AGT: Diabetes + prediabetes (n = 40)] and Group B: normal glucose tolerance (NGT) (n = 50).The impact of the following parameters: age, sex, Waist Circumference(WC), Body Mass Index (BMI), duration of acromegaly, Growth Hormone (GH) levels, Insulin like Growth Factor 1 (IGF1) levels, pituitary tumour size, hypertension, and family history of diabetes as predictors for diabetes were studied pre surgery and post-surgery at 3 months and 1 year affecting glycaemia. Unpaired t-test, chi-square test and binary logistic regression analysis were used for statistical analysis.

Results

The prevalence of AGT in our cohort was 44.44% (Diabetes 37.77%, prediabetes 6.66%).Patients with AGT were older (44.2 ± 12.21 years vs. 34.92 ± 11.62 years; p = 0.00040) and had higher WC (in cm) (91.35 ± 7.87 vs.87.12 ± 6.07; p = 0.005) than NGT. Hypertension and family history of diabetes were significantly more frequent in patients with AGT. GH and IGF1 levels were not significantly different between the groups. On binary logistic regression, Sex (p = 0.0105) (OR = 6.0985), waist circumference (p = 0.0023) (OR = 1.2276) and hypertension (p = 0.0236) (OR = 1.632) were found to be significant predictors of AGT in acromegaly. After surgery 42.5% and 62.5% patients became normoglycemic at 3 months and 1 year respectively. On binary logistic regression there were no predictors for achieving normoglycemia at 3 months or 1 year, however the delta change in GH, BMI and tumour size were significant.

Conclusions

The prevalence of AGT was 44.44%. Female sex, WC and hypertension were found to be significant predictors of AGT in acromegaly. Post-surgery normoglycemia was achieved in 42.5% at 3 months and 62.5% at 1 year with no predictors for normalisation of AGT.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
期刊最新文献
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