伴有或不伴有融合性发育不良性眼震的弱视患者的单眼和双眼视觉功能障碍。

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2021-04-28 eCollection Date: 2021-01-01 DOI:10.2147/EB.S300454
Jordan Murray, Kiran Garg, Fatema Ghasia
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引用次数: 0

摘要

目的:本研究旨在探讨弱视类型与眼球震颤对同视眼(FE)和弱视眼(AE)的双眼功能和单眼功能的影响:我们招募了19名对照组患者和44名弱视患者(异视=13,斜视=10,混合视=21)。我们采用阶梯法测量了每只眼睛的视力、光栅和游标视力以及高/低空间频率(SF)对比敏感度。立体视敏度通过 Titmus 苍蝇试验进行测量。我们使用高分辨率视频眼动仪记录固定眼球运动(FEM)。受试者被分为无眼球震颤(18 人)、融合发育不良性眼球震颤综合征(FMNS)(12 人)或无任何结构异常且不符合 FMNS 或婴儿眼球震颤标准的眼球震颤(14 人):结果:根据临床弱视类型对视觉功能进行的分析表明,斜视/混合性弱视患者(F (2,54)=9.5, pConclusion.)存在FMNS:斜视/混合性弱视患者出现 FMNS 与立体视不良/无立体视有关。不同弱视类型的 FE 缺陷各不相同。与眼球震颤异常一样,有眼球震颤和无眼球震颤患者的视功能也存在缺陷。
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Monocular and Binocular Visual Function Deficits in Amblyopic Patients with and without Fusion Maldevelopment Nystagmus.

Purpose: The aim of the study is to examine the association between amblyopia type and the presence of nystagmus on binocular and monocular functions of the fellow (FE) and amblyopic eye (AE).

Methods: We recruited 19 controls and 44 amblyopes (anisometropes=13, strabismic=10, mixed=21). We measured visual, grating, and vernier acuities and high/low spatial frequency (SF) contrast sensitivities in each eye using a staircase method. Stereoacuity was measured with the Titmus fly test. We recorded fixation eye movements (FEM) using high-resolution video-oculography. Subjects were classified as having either no nystagmus (n=18), fusion maldevelopment nystagmus syndrome (FMNS) (n=12), or nystagmus without any structural anomalies that does not meet the criteria for FMNS or infantile nystagmus (n=14).

Results: Analysis of visual function by clinical amblyopia type showed that patients with strabismus/mixed amblyopia (F (2,54)=9.5, p<0.001) were more likely to have poor stereopsis while controlling for AE grating acuity deficit. The FE of patients with anisometropia had greater contrast sensitivity deficits at low (F (2,43)=4.4, p=0.018) and high SF (F (2,42)=10.1, p<0.001). Analysis of visual function by FEM characteristics (low SF: (F (3,43)=4.3, p=0.010) and high SF: (F (3,42)=7.1, p=0.001) showed that the FE of patients with FMNS had worse low and high SF contrast sensitivities, whereas those without FMNS had greater contrast sensitivity deficits only at high SF compared to controls. Patients with FMNS (F (3,54) = 12.9, p<0.001) were more likely to have poor stereopsis while controlling for AE grating acuity deficit compared to patients without FMNS. All amblyopic patients had worse high SF contrast sensitivity of the AE irrespective of type or FEM characteristics (Type = F (2,43)=8.8, p=0.001; FEM characteristics= F (3,43)=5.1, p=0.004).

Conclusion: The presence of FMNS in patients with strabismic/mixed amblyopia is associated with poor/absent stereopsis. FE deficits vary across amblyopia type. Like FEM abnormalities, visual function deficits are seen in the FE of patients with and without nystagmus.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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