肢端肥大症患者的泪腺增大和泪膜改变:一项对照研究

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2021-08-01 DOI:10.1016/j.ghir.2021.101397
Burak Mergen , Ceyhun Arici , Osman Kizilkilic , Necmettin Tanriover , Pinar Kadioglu
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引用次数: 1

摘要

目的评价肢端肥大症患者泪腺体积(LGV)及其与泪膜功能、血清生长激素(GH)、胰岛素样生长因子-1 (IGF-1)水平的相关性。方法本前瞻性病例对照研究包括38例未控制(UA)患者、48例控制性肢端肥大症(CA)患者和44例无功能垂体腺瘤患者的眼睛。在基线、第3个月和第6个月通过磁共振成像评估患者的LGV。在同一次就诊时评估Schirmer试验、泪液破裂时间(TBUT)和眼表疾病指数(OSDI)评分。研究其与血清IGF-1和GH的相关性。主要结局指标为平均LGV的差异。结果肢端肥大症患者基线访视时的平均LGV(116.0±33.2 mm3)和第3个月访视时的平均LGV(119.5±36.4 mm3)高于对照组(65.2±22.3 mm3和63.2±22.3 mm3);p & lt;0.001),在连续三次就诊中UA和CA患者的LGV无显著差异(p >0.05)。在所有患者中,IGF-1和GH水平与LGV呈正相关(p <0.001;r = 0.52;R = 0.6)。然而,每次就诊时三组间的Schirmer、TBUT和OSDI评分均无差异(p >0.05)。结论肢端肥大症患者的泪腺比对照组大,且与IGF-1和GH水平升高有关。泪腺体积可能对其泪膜相关功能没有影响。
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Lacrimal gland enlargement and tear film changes in acromegaly patients: A controlled study

Purpose

Evaluation of the lacrimal gland volume (LGV) and its correlation with tear film functions, serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in acromegaly patients compared to a control group was aimed.

Methods

This prospective case-control study included the eyes of 38 patients with uncontrolled (UA) and 48 patients with controlled acromegaly (CA) and 44 patients with nonfunctioning pituitary adenoma. LGV of the patients was evaluated at the baseline, 3rd, and 6th-month visits with magnetic resonance imaging. Schirmer's test, tear breakup time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at the same visits. Their correlation with serum IGF-1 and GH was investigated. Main outcome measure was the difference in mean LGV.

Results

The mean LGV of the acromegaly patients at the baseline visit (116.0 ± 33.2 mm3) and the 3rd-month visit (119.5 ± 36.4 mm3) was higher than the control group (65.2 ± 22.3 mm3 and 63.2 ± 22.3 mm3, respectively; p < 0.001) without any significant difference between the UA and CA patients in the LGV in three consecutive visits (p > 0.05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (p < 0.001; r = 0.52; r = 0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (p > 0.05).

Conclusion

Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
期刊最新文献
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