Lessons from the Fukushima Daiichi nuclear power plant accident -from a research perspective.

Since the accident at Fukushima Daiichi nuclear power plant, there has been a focus on the impact of low-dose radiation exposure due to nuclear disasters and radiology on human bodies. In order to study very low levels of impact on the human body from low-dose radiation exposure, a system with high detection sensitivity is needed. Until now, the most well-established biological radiation effect detection system in the field of emergency radiation medicine has been chromosomal analysis. However, chromosomal analysis requires advanced skills, and it is necessary to perform chromosomal analysis of a large number of cells in order to detect slight effects on the human body due to low-dose radiation exposure. Therefore, in order to study the effects of low-dose radiation exposure on the human body, it is necessary to develop high-throughput chromosome analysis technology. We have established the PNA-FISH method, which is a fluorescence in-situ hybridisation method using a PNA probe, as a high-throughput chromosome analysis technique. Using this method, the detection of dicentrics and ring chromosomes has become very efficient. Using this technology, chromosomal analysis was performed on peripheral blood before and after computed tomography (CT) examination of patients at Hiroshima University Hospital, and it was possible to detect chromosomal abnormalities due to low-dose radiation exposure in the CT examination. Furthermore, it was shown that there may be individual differences in the increase in chromosomal abnormalities due to low-dose radiation exposure, suggesting the need to build a next-generation medical radiation exposure management system based on individual differences in radiation sensitivity. If techniques such as chromosomal analysis, which have been used for biological dose evaluation in emergency radiation medicine, can be used for general radiology, such as radiodiagnosis and treatment, that will be a contribution to radiology from an unprecedented angle. This article will discuss the clinical application of new biological dose evaluation methods that have been developed in the field of emergency radiation medicine.