大麻素受体2型配体:2010年以来授权专利分析。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2021-05-01 Epub Date: 2021-06-11 DOI:10.4155/ppa-2021-0002
Benjamin Brennecke, Thais Gazzi, Kenneth Atz, Jürgen Fingerle, Pascal Kuner, Torsten Schindler, Guy de Weck, Marc Nazaré, Uwe Grether
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引用次数: 9

摘要

g蛋白偶联大麻素受体2型(CB2R)是内源性大麻素(EC)系统的关键元件。EC/CB2R信号在过敏、神经退行性疾病、炎症或眼部疾病等影响人类的主要病理中具有重要的治疗潜力。CB2R激动剂在心血管、胃肠、肝、肾、肺和神经退行性疾病的临床前动物模型中具有抗炎和组织保护作用。现有的配体可细分为内源性大麻素(endocannabinoids)、类大麻素(cannabinoids -样大麻素)和合成CB2R配体,对大麻素受体1型具有不同程度的效力和选择性。本文回顾了2010年至今CB2R配体的授权专利,这些专利使用Derwent Innovation®进行了调查。
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Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010.

The G-protein-coupled cannabinoid receptor type 2 (CB2R) is a key element of the endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB2R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB2R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB2R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation®.

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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
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发文量
22
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