安全可行的震动运动疗法对SAMP-10小鼠杏仁核-海马回路功能的维持

IF 1.4 Q4 CLINICAL NEUROLOGY Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2021-05-19 eCollection Date: 2021-05-01 DOI:10.1159/000515957
Runhong Yao, Kazuhiro Nishii, Naoki Aizu, Takumi Kito, Kazuyoshi Sakai, Kouji Yamada
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引用次数: 4

摘要

引言:痴呆症患者对环境威胁的适应、行为和生理反应减弱。体育锻炼有望延缓大脑衰老,保持认知功能,从而帮助痴呆症患者面对威胁并巧妙地保护自己。方法:为了证实这一点,我们旨在从行为和组织水平上研究摇晃运动对衰老加速小鼠倾向性菌株10(SAMP-10)模型回避功能的影响。SAMP-10小鼠随机分为2组:对照组和摇动组。使用被动回避任务评估小鼠的回避反应(潜伏期)。根据大脑形态学评估杏仁核和海马的衰老程度。随后,评估了回避反应与杏仁核-海马衰老程度之间的关系。结果:在被动回避任务方面,摇晃组表现出比对照组更长的潜伏期(p<0.05),泛素化蛋白染色均匀且低强度,神经元数量和体积比对照组更多。两组之间的差异在杏仁核BA区和海马CA1区(染色程度:p<0.05,神经元大小:p<0.01,神经元计数:p<0.01)比其他区域更显著。结论:摇动运动可防止非功能蛋白(NFP)积累、神经元萎缩和神经元丢失;延缓杏仁核和海马体的衰老;并维持杏仁核-海马回路的功能。从而增强情绪处理和认知功能,增强对威胁的记忆,熟练对抗威胁,以及适当的自我保护。
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Maintenance of the Amygdala-Hippocampal Circuit Function with Safe and Feasible Shaking Exercise Therapy in SAMP-10 Mice.

Introduction: Patients with dementia show reduced adaptive, behavioral, and physiological responses to environmental threats. Physical exercise is expected to delay brain aging, maintain cognitive function and, consequently, help dementia patients face threats and protect themselves skillfully.

Methods: To confirm this, we aimed to investigate the effects of the shaking exercise on the avoidance function in the senescence-accelerated mouse-prone strain-10 (SAMP-10) model at the behavioral and tissue levels. SAMP-10 mice were randomized into 2 groups: a control group and a shaking group. The avoidance response (latency) of the mice was evaluated using a passive avoidance task. The degree of amygdala and hippocampal aging was evaluated based on the brain morphology. Subsequently, the association between avoidance response and the degree of amygdala-hippocampal aging was evaluated.

Results: Regarding the passive avoidance task, the shaking group showed a longer latency period than the control group (p < 0.05), even and low intensity staining of ubiquitinated protein, and had a higher number of and larger neurons than those of the control group. The difference between the groups was more significant in the BA region of the amygdala and the CA1 region of the hippocampus (staining degree: p < 0.05, neuron size: p < 0.01, neuron counts: p < 0.01) than in other regions.

Conclusions: The shaking exercise prevents nonfunctional protein (NFP) accumulation, neuron atrophy, and neuron loss; delays the aging of the amygdala and hippocampus; and maintains the function of the amygdala-hippocampal circuit. It thus enhances emotional processing and cognition functions, the memory of threats, the skillful confrontation of threats, and proper self-protection from danger.

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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
期刊最新文献
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