Ozel Yuruker, Ceyhun Dalkan, Murat Uncu, Osman Yetkin, Arzu Babayigit, Nerin N Bahceciler
{"title":"高胎儿双酚A暴露增加il - 22分泌:一种促炎细胞因子。","authors":"Ozel Yuruker, Ceyhun Dalkan, Murat Uncu, Osman Yetkin, Arzu Babayigit, Nerin N Bahceciler","doi":"10.12932/AP-020320-0778","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is an industrial product, widely used in human consumed types of equipment that can be transmitted orally, by inhalation or through dermal absorption and is detectable in many body fluids including cord blood. A correlation between BPA concentration in maternal serum and cord blood has been demonstrated previously, suggesting a possible transfer of BPA via the transplacental path.</p><p><strong>Objective: </strong>Our objective is to determine the impact of cord blood BPA level on cytokine responses.</p><p><strong>Methods: </strong>In this cross-sectional study, healthy pregnant women who delivered healthy newborns followed by the Obstetrics and Gynecology Department between September 2016 to June 2017 were enrolled. Cord blood samples were obtained and BPA and IL4, IL5, IL10, IL17, IL22, IFN gama and TGF beta levels were studied by ELISA.</p><p><strong>Results: </strong>Among 197 deliveries, 176 of them were included in the study. Due to lack of cut-off value, BPA levels were stratified as percentiles. No statistically significant difference was detected in comparison of cytokine levels based on BPA concentrations below and above the 25th and 50th percentiles. Significantly higher IL22 levels (p = 0.007) and increased ratio of IL22/TGFβ (p = 0.04) were detected in those with BPA level above 75th percentile (>19.16 ng/ml) compared to the below group.</p><p><strong>Conclusions: </strong>This in vivo real-life study demonstrated that very high BPA levels in cord blood of expectant mothers enhances IL22 secretion in cord blood which is a proinflammatory cytokine. Studies evaluating long term immunological effects on those highly exposed newborns are necessitated.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"396-400"},"PeriodicalIF":2.3000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"High fetal bisphenol A exposure enhances IL22 secretion: A proinflammatory cytokine.\",\"authors\":\"Ozel Yuruker, Ceyhun Dalkan, Murat Uncu, Osman Yetkin, Arzu Babayigit, Nerin N Bahceciler\",\"doi\":\"10.12932/AP-020320-0778\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bisphenol A (BPA) is an industrial product, widely used in human consumed types of equipment that can be transmitted orally, by inhalation or through dermal absorption and is detectable in many body fluids including cord blood. A correlation between BPA concentration in maternal serum and cord blood has been demonstrated previously, suggesting a possible transfer of BPA via the transplacental path.</p><p><strong>Objective: </strong>Our objective is to determine the impact of cord blood BPA level on cytokine responses.</p><p><strong>Methods: </strong>In this cross-sectional study, healthy pregnant women who delivered healthy newborns followed by the Obstetrics and Gynecology Department between September 2016 to June 2017 were enrolled. Cord blood samples were obtained and BPA and IL4, IL5, IL10, IL17, IL22, IFN gama and TGF beta levels were studied by ELISA.</p><p><strong>Results: </strong>Among 197 deliveries, 176 of them were included in the study. Due to lack of cut-off value, BPA levels were stratified as percentiles. No statistically significant difference was detected in comparison of cytokine levels based on BPA concentrations below and above the 25th and 50th percentiles. Significantly higher IL22 levels (p = 0.007) and increased ratio of IL22/TGFβ (p = 0.04) were detected in those with BPA level above 75th percentile (>19.16 ng/ml) compared to the below group.</p><p><strong>Conclusions: </strong>This in vivo real-life study demonstrated that very high BPA levels in cord blood of expectant mothers enhances IL22 secretion in cord blood which is a proinflammatory cytokine. Studies evaluating long term immunological effects on those highly exposed newborns are necessitated.</p>\",\"PeriodicalId\":8552,\"journal\":{\"name\":\"Asian Pacific journal of allergy and immunology\",\"volume\":\" \",\"pages\":\"396-400\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Pacific journal of allergy and immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12932/AP-020320-0778\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific journal of allergy and immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12932/AP-020320-0778","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 2
摘要
背景:双酚A (BPA)是一种工业产品,广泛用于人类消费的各类设备,可通过口服、吸入或皮肤吸收传播,并可在包括脐带血在内的许多体液中检测到。母体血清和脐带血中BPA浓度之间的相关性先前已被证实,这表明BPA可能通过经胎盘途径转移。目的:我们的目的是确定脐带血BPA水平对细胞因子反应的影响。方法:在本横断面研究中,纳入2016年9月至2017年6月期间在妇产科随访的分娩健康新生儿的健康孕妇。采集脐带血样本,采用ELISA法检测BPA和IL4、IL5、IL10、IL17、IL22、IFN γ、TGF β水平。结果:197例分娩中,176例纳入研究。由于缺乏临界值,双酚a水平以百分位数分层。BPA浓度高于25百分位和低于50百分位时,细胞因子水平的差异无统计学意义。BPA水平高于75百分位组(>19.16 ng/ml), il - 22水平显著高于对照组(p = 0.007), il - 22/ tgf - β比值显著高于对照组(p = 0.04)。结论:本研究表明,孕妇脐带血中BPA含量高,可促进脐带血中促炎细胞因子il - 22的分泌。有必要研究评估对高暴露新生儿的长期免疫影响。
High fetal bisphenol A exposure enhances IL22 secretion: A proinflammatory cytokine.
Background: Bisphenol A (BPA) is an industrial product, widely used in human consumed types of equipment that can be transmitted orally, by inhalation or through dermal absorption and is detectable in many body fluids including cord blood. A correlation between BPA concentration in maternal serum and cord blood has been demonstrated previously, suggesting a possible transfer of BPA via the transplacental path.
Objective: Our objective is to determine the impact of cord blood BPA level on cytokine responses.
Methods: In this cross-sectional study, healthy pregnant women who delivered healthy newborns followed by the Obstetrics and Gynecology Department between September 2016 to June 2017 were enrolled. Cord blood samples were obtained and BPA and IL4, IL5, IL10, IL17, IL22, IFN gama and TGF beta levels were studied by ELISA.
Results: Among 197 deliveries, 176 of them were included in the study. Due to lack of cut-off value, BPA levels were stratified as percentiles. No statistically significant difference was detected in comparison of cytokine levels based on BPA concentrations below and above the 25th and 50th percentiles. Significantly higher IL22 levels (p = 0.007) and increased ratio of IL22/TGFβ (p = 0.04) were detected in those with BPA level above 75th percentile (>19.16 ng/ml) compared to the below group.
Conclusions: This in vivo real-life study demonstrated that very high BPA levels in cord blood of expectant mothers enhances IL22 secretion in cord blood which is a proinflammatory cytokine. Studies evaluating long term immunological effects on those highly exposed newborns are necessitated.
期刊介绍:
The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747
APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume.
APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand.
The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.