Lina Leng , Yuling Xing , Yi Liang , Chang Wang , Huijuan Ma
{"title":"成人循环胰岛素样生长因子-1与血压的关系:观察性研究的系统回顾和荟萃分析","authors":"Lina Leng , Yuling Xing , Yi Liang , Chang Wang , Huijuan Ma","doi":"10.1016/j.ghir.2021.101416","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood pressure (BP). Nevertheless, the results were inconsistent. Thus, the purpose of this study was to systematically evaluate the associations of circulating IGF-1 levels with BP in adults.</p></div><div><h3>Methods</h3><p><span>Two reviewers independently searched and screened articles from the Pubmed, EMBASE, Cochrane Library, CNKI, and WANFANG databases up to May 2020. A total of 12 studies that reported the correlation coefficients between IGF-1, </span>systolic blood pressure<span> (SBP), and diastolic blood pressure (DBP) were included.</span></p></div><div><h3>Results</h3><p>IGF-1 was significantly correlated with SBP [<em>r</em> = −0.15; 95% CI = −0.21, −0.08; <em>P</em> < 0.0001] and DBP [<em>r</em> = −0.10; 95% CI = −0.16, −0.05; <em>P</em> = 0.0004]. Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age.</p></div><div><h3>Conclusion</h3><p>Circulating IGF-1 was negatively correlated with SBP and DBP. Further researches are necessary to explore the pathogenesis of this relationship and to evaluate the role of IGF-1 in the treatment of hypertension.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"60 ","pages":"Article 101416"},"PeriodicalIF":1.6000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101416","citationCount":"1","resultStr":"{\"title\":\"Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies\",\"authors\":\"Lina Leng , Yuling Xing , Yi Liang , Chang Wang , Huijuan Ma\",\"doi\":\"10.1016/j.ghir.2021.101416\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood pressure (BP). Nevertheless, the results were inconsistent. Thus, the purpose of this study was to systematically evaluate the associations of circulating IGF-1 levels with BP in adults.</p></div><div><h3>Methods</h3><p><span>Two reviewers independently searched and screened articles from the Pubmed, EMBASE, Cochrane Library, CNKI, and WANFANG databases up to May 2020. A total of 12 studies that reported the correlation coefficients between IGF-1, </span>systolic blood pressure<span> (SBP), and diastolic blood pressure (DBP) were included.</span></p></div><div><h3>Results</h3><p>IGF-1 was significantly correlated with SBP [<em>r</em> = −0.15; 95% CI = −0.21, −0.08; <em>P</em> < 0.0001] and DBP [<em>r</em> = −0.10; 95% CI = −0.16, −0.05; <em>P</em> = 0.0004]. Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age.</p></div><div><h3>Conclusion</h3><p>Circulating IGF-1 was negatively correlated with SBP and DBP. Further researches are necessary to explore the pathogenesis of this relationship and to evaluate the role of IGF-1 in the treatment of hypertension.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":\"60 \",\"pages\":\"Article 101416\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101416\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637421000393\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637421000393","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies
Objective
Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood pressure (BP). Nevertheless, the results were inconsistent. Thus, the purpose of this study was to systematically evaluate the associations of circulating IGF-1 levels with BP in adults.
Methods
Two reviewers independently searched and screened articles from the Pubmed, EMBASE, Cochrane Library, CNKI, and WANFANG databases up to May 2020. A total of 12 studies that reported the correlation coefficients between IGF-1, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were included.
Results
IGF-1 was significantly correlated with SBP [r = −0.15; 95% CI = −0.21, −0.08; P < 0.0001] and DBP [r = −0.10; 95% CI = −0.16, −0.05; P = 0.0004]. Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age.
Conclusion
Circulating IGF-1 was negatively correlated with SBP and DBP. Further researches are necessary to explore the pathogenesis of this relationship and to evaluate the role of IGF-1 in the treatment of hypertension.
期刊介绍：
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
