阿根廷布宜诺斯艾利斯血液透析患者的肌肉减少症

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Osteoporosis and Sarcopenia Pub Date : 2021-06-01 DOI:10.1016/j.afos.2021.04.001
Ruben Abdala , Elisa Elena del Valle , Armando Luis Negri , Pablo Bridoux , Luciana Gonzalez Paganti , Marina Bravo , Luis Sintado , Paula Di Rienzo , Omar R. Schiavelli , Maria Belén Zanchetta , Adrián Guinsburg
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引用次数: 5

摘要

目的骨骼肌减少症是骨骼肌质量和功能的丧失,随着年龄的增长而发生,可导致更高的发病率和死亡率。慢性肾脏疾病和血液透析(HD)有利于肌肉减少症的发展。我们使用欧洲老年人肌少症工作组提出的HD患者肌少症发展标准和危险因素研究了肌少症的患病率及其组成部分。方法对100例成人HD患者进行了手握力(HGS)、双能x线骨密度测量法测定肌肉质量和体能表现(步态-速度和坐立测试)评估。结果男性60例,女性40例;平均年龄55.6岁。肌肉减少症患病率为16%(男性11.1%,女性25%;p = 0.05);7%患有严重的肌肉减少症。低HGS患病率男性为33%,女性为28%;肌肉质量低的男性占30%,女性占70%,体能表现低的男性占23%,女性占45%。23例患者报告跌倒。HGS较低的患者在过去一年中跌倒的发生率较高(40%有两次或两次以上跌倒;p = 0.03)。只有患有肌肉减少症的女性骨矿物质含量较低。年龄、体重指数、透析时间和糖尿病患病率都不能预测肌肉减少症。结论透析患者中肌肉减少症发生率较高,以女性多见。低HGS与较高的跌倒发生率相关。只有患有肌肉减少症的女性骨矿物质含量较低。
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Sarcopenia in hemodialysis patients from Buenos Aires, Argentina

Objectives

Sarcopenia is the loss of skeletal muscle mass and function that occurs with aging that can lead to greater morbidity and mortality. Chronic kidney disease and hemodialysis (HD) favors the development of sarcopenia. We studied the prevalence of sarcopenia and its components using European Working Group on Sarcopenia in Elderly People 2 proposed criteria and risk factors for its development in HD patients.

Methods

In 100 adult HD patients, we evaluated: hand grip strength (HGS), muscle mass by dual energy X-ray absorptiometry and physical performance (gait-speed and sit-stand test).

Results

Sixty patients were male and 40 were female; mean age 55.6 years. Prevalence of sarcopenia was 16% (11.1% in males and 25% in females; P = 0.05); 7% had severe sarcopenia. Prevalence of low HGS was 33% in males and 28% in females; low muscle mass was 30% in males but 70% in females and low physical performance 23% in males and 45% in females. Falls were reported by 23 patients. Patients with lower HGS had a higher prevalence of falls in the last year (40% two or more falls; P = 0.03). Only females with sarcopenia had lower bone mineral content. Neither age, body mass index, time on dialysis, or prevalence of diabetes predicted sarcopenia.

Conclusions

A significant proportion of dialysis patients had sarcopenia, more frequent in females. Low HGS was associated with a higher prevalence of falls. Only females with sarcopenia had lower bone mineral content.

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来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
5.00%
发文量
23
审稿时长
66 days
期刊最新文献
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